ArticleGut2002
An insight into the genetic pathway of adenocarcinoma of the small intestine.
Article in Gut, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 141 citations in OpenAlex.
- Small bowel adenocarcinoma in Crohn's disease: a systematic review and meta-analysis of the prevalence, manifestation, histopathology, and outcomes.International journal of colorectal disease · 2022Pooled it
- Primary adenocarcinoma of duodenal bulb mimicking a pancreatic tumor: a case report.Future science OA · 2025Article
- Article
- Bibliometrics analysis on the research status and trends of small bowel adenocarcinoma: 1923-2023.Frontiers in oncology · 2024Review
- Small bowel intussusception caused by a serrated adenoma: a case report.The Journal of international medical research · 2022Article
- Identification of Lynch Syndrome Carriers among Patients with Small Bowel Adenocarcinoma.Cancers · 2021Article
- Prognostic Factors and Clinical Characteristics of Duodenal Adenocarcinoma With Survival: A Retrospective Study.Frontiers in oncology · 2021Article
- Epidemiology of Cancers of the Small Intestine: Trends, Risk Factors, and Prevention.Medical sciences (Basel, Switzerland) · 2019Review
- Primary small bowel adenomas and adenocarcinomas-recent advances.Virchows Archiv : an international journal of pathology · 2018Review
- APC:T1556fs and STK11 mutations in duodenal adenomas and adenocarcinomas.Surgery today · 2018Article
- Exome-wide somatic mutation characterization of small bowel adenocarcinoma.PLoS genetics · 2018Article
- Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) as a Useful Immunohistochemical Marker for the Diagnosis of Adenocarcinoma of Small Intestine.Acta histochemica et cytochemica · 2015Article
- Primary small-bowel malignancy: update in tumor biology, markers, and management strategies.Journal of gastrointestinal cancer · 2014Review
- CpG island methylator phenotype and its association with malignancy in sporadic duodenal adenomas.Epigenetics · 2014Article
- Jejunal Cancer with WRN Mutation Identified from Next-Generation Sequencing: A Case Study and Minireview.Case reports in surgery · 2014Article
- Small bowel adenocarcinoma phenotyping, a clinicobiological prognostic study.British journal of cancer · 2013Article
- Small bowel adenocarcinomas--existing evidence and evolving paradigms.Nature reviews. Clinical oncology · 2013Review
- Small bowel adenocarcinoma - report of two cases and review of literature.The Indian journal of surgery · 2013Review
- DPC4 expression in the small intestinal adenocarcinomas.Korean journal of pathology · 2012Article
- Superior prognostic importance of perineural invasion vs. lymph node involvement after curative resection of duodenal adenocarcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the adenoma to carcinoma pathway in colorectal cancer is well described, the mechanisms of carcinogenesis in the small intestine remain unclear.
aimsThe aim of this study was to investigate candidate genes in the genetic pathway of adenocarcinoma of the small intestine. SUBJECTS AND
methodsA total of 21 non-familial, non-ampullary adenocarcinomas of the small intestine were analysed. DNA was extracted from formalin fixed paraffin wax embedded tissue using standard techniques. The replication error (RER) status was determined by amplification of BAT26. The mutation cluster region (MCR) of the adenomatous polyposis coli (APC) gene was screened using polymerase chain reaction single strand conformational polymorphism and direct sequencing. Immunohistochemistry was performed on formalin fixed paraffin wax embedded tissue using monoclonal antibodies for hMLH1, hMSH2, beta-catenin, E-cadherin, and p53.
resultsFourteen male and seven female patients with a median age of 64 years (range 21-85) presented with adenocarcinoma of the duodenum (10), jejunum (7), and ileum (4). One cancer (5%) was found to be RER+, and all tumours stained positive for hMLH1 and hMSH2. No mutations were detected in the MCR of the APC gene. beta-Catenin showed increased nuclear expression with loss of membranous staining in 10 cancers (48%). Absent or decreased membrane expression of E-cadherin was found in eight cancers (38%). Strong staining of p53 was found in the nucleus of five cancers (24%).
conclusionWe did not detect mutations in the MCR of the APC gene, and this suggests that adenocarcinoma of the small intestine may follow a different genetic pathway to colorectal cancer. Abnormal expression of E-cadherin and beta-catenin was common and reflects an early alternative to APC in this pathway in which mutations may be found in adenocarcinoma of the small intestine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.