ArticleGut2002
Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease.
Article in Gut, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 154 citations in OpenAlex.
- Diet and psoriasis, part II: celiac disease and role of a gluten-free diet.Journal of the American Academy of Dermatology · 2014Pooled it
- Serum cytokine pattern in young children with screening detected coeliac disease.Clinical and experimental immunology · 2015Trial
- Immune cell dynamics and mechanisms of epithelial injury in celiac disease.Frontiers in immunology · 2026Review
- Celiac Disease-Narrative Review on Progress in Celiac Disease.Foods (Basel, Switzerland) · 2025Review
- Celiac disease is associated with increased risk of deep vein thrombosis and hypotensive shock in patients admitted with acute pancreatitis.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Association of celiac disease with eosinophilic esophagitis: Nationwide register-based cohort study with sibling analyses.The journal of allergy and clinical immunology. Global · 2024Article
- Role of interleukin-18 in mediating the impacts of celiac disease on osteoporosis: a Mendelian randomization study.Frontiers in immunology · 2024Article
- PIM kinases regulate early human Th17 cell differentiation.Cell reports · 2023Article
- Article
- Artificial Intelligence Analysis of Celiac Disease Using an Autoimmune Discovery Transcriptomic Panel Highlighted Pathogenic Genes including BTLA.Healthcare (Basel, Switzerland) · 2022Article
- Transcriptomics of type 2 diabetic and healthy human neutrophils.BMC immunology · 2021Article
- mTOR sustains inflammatory response in celiac disease.Scientific reports · 2020Article
- Intestinal Anti-tissue Transglutaminase2 Autoantibodies: Pathogenic and Clinical Implications for Celiac Disease.Frontiers in nutrition · 2020Review
- Digestive system in psoriasis: an update.Archives of dermatological research · 2017Review
- Article
- Sensitization to and Challenge with Gliadin Induce Pancreatitis and Extrapancreatic Inflammation in HLA-DQ8 Mice: An Animal Model of Type 1 Autoimmune Pancreatitis.Gut and liver · 2016Article
- Immunogenetic Pathogenesis of Celiac Disease and Non-celiac Gluten Sensitivity.Current gastroenterology reports · 2016Review
- In the Intestinal Mucosa of Children With Potential Celiac Disease IL-21 and IL-17A are Less Expressed than in the Active Disease.The American journal of gastroenterology · 2016Article
- Elderly Onset Celiac Disease: A Narrative Review.Clinical medicine insights. Gastroenterology · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoeliac disease (CD) is caused by a T helper cell type 1 (Th1) response in the small intestinal mucosa to dietary gluten. Paradoxically, interleukin (IL)-12, the major Th1 inducing factor, is undetectable in the mucosa of active CD. IL-18 is a recently described cytokine capable of promoting T cell interferon (IFN)-gamma production and facilitating Th1 cell polarisation.
aimTo examine expression of IL-18 and IL-18-associated Th1 proteins in CD.
methodsIL-18 and IFN-gamma RNA transcripts were determined by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). IL-18 and caspase-1 protein expression were assessed by western blotting. Caspase-1 activity was determined using a commercially available assay. RNA transcripts for the IL-18 receptor subunits, IL-1 receptor related protein (IL-1 Rrp) and accessory protein-like subunit (AcPL), and IL-18 induced Th1 specific T box transcription factor (T-bet) were measured by RT-PCR and Southern blotting.
resultsIL-18 RNA transcripts were found in all mucosal samples analysed, with no difference between CD patients and controls. By western blot analysis, a large protein of approximately 24 kDa, corresponding to the immature IL-18, was detected in all mucosal samples from CD patients and controls. In contrast, mature IL-18 was only seen in CD patients. Immunoreactivity corresponding to both immature and mature caspase-1 was present in both CD and control samples. Tissue homogenates from CD patients and controls expressed similar levels of caspase-1 activity. IL-1Rrp and AcPL were seen in all samples but were expressed at greater levels in the mucosa of CD patients. T-bet was also upregulated in CD.
conclusionsActive IL-18 is expressed in CD as well as other markers of Th1 polarisation.
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