ArticleBritish journal of pharmacology2002
In vivo evidence for a role of protein kinase C in peripheral nociceptive processing.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 65 citations in OpenAlex.
- Activating PKC-ε induces HIV expression with improved tolerability.PLoS pathogens · 2025Article
- Antinociceptive Activity of Methanolic Extract ofPain research & management · 2018Article
- The leguminous lectin of Lonchocarpus araripensis promotes antinociception via mechanisms that include neuronal inhibition of Na(+) currents.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Intact subepidermal nerve fibers mediate mechanical hypersensitivity via the activation of protein kinase C gamma in spared nerve injury.Molecular pain · 2016Article
- Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes.Frontiers in pharmacology · 2015Review
- Whiplash-like facet joint loading initiates glutamatergic responses in the DRG and spinal cord associated with behavioral hypersensitivity.Brain research · 2012Article
- Isozyme-specific effects of protein kinase C in pain modulation.Anesthesiology · 2011Article
- TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The role of PKA and PKCepsilon pathways in prostaglandin E2-mediated hypernociception.British journal of pharmacology · 2009Article
- Peripheral delta opioid receptors require priming for functional competence in vivo.European journal of pharmacology · 2009Article
- Intracellular signaling in primary sensory neurons and persistent pain.Neurochemical research · 2008Review
- Protein kinase C in pain: involvement of multiple isoforms.Pharmacological research · 2007Review
- Modulation of sensory neuron mechanotransduction by PKC- and nerve growth factor-dependent pathways.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- A cascade of cytokines mediates mechanical inflammatory hypernociception in mice.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Restoration of spontaneous exploratory behaviors with an intrathecal NMDA receptor antagonist or a PKC inhibitor in rats with acute pancreatitis.Pharmacology, biochemistry, and behavior · 2004Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The present study was designed to characterize the nociceptive response induced by protein kinase C (PKC) peripheral activation and to investigate if this biochemical event is important for the nociceptive response induced by formaldehyde, and bradykinin (BK). 2. Intraplantar injection of phorbol-12,13-didecanoate (PDD; 0.01, 0.1 or 1 microg), a PKC activator, but not of 4 alpha-PDD (inactive analogue), dose-dependently induced thermal hyperalgesia in rats. This response was not observed at the contralateral hindpaw. Intraplantar injection of PDD (0.01, 0.1 or 1 microg) also induced mechanical allodynia. In mice, injection of PDD (0.1 or 1 microg) into the dorsum of the hindpaw induced a spontaneous licking behaviour. 3. Intraplantar co-injection of chelerythrine (10 or 50 microg), a PKC inhibitor, attenuated the thermal hyperalgesia induced by PDD (0.1 microg) in rats. 4. The second phase of the nociceptive response induced by the injection of formaldehyde (0.92%, 20 microl) into the dorsum of mice hindpaws was inhibited by ipsi-, but not contralateral, pre-treatment with chelerythrine (1 microg). 5. Intraplantar injection of BK (10 microg) induced mechanical allodynia in rats. Ipsi- but not contralateral injection of bisindolylmaleimide I (10 microg), a PKC inhibitor, inhibited BK-induced mechanical allodynia. 6. In conclusion, this study demonstrates that PKC activation at peripheral tissues leads to the development of spontaneous nociceptive response, thermal hyperalgesia and mechanical allodynia. Most importantly, it also gives in vivo evidence that peripheral PKC activation is essential for the full establishment of the nociceptive response induced by two different inflammatory stimuli.
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