ArticleBritish journal of pharmacology2002
Endothelium-dependent hyperpolarization and relaxation in mesenteric arteries of middle-aged rats: influence of oestrogen.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 67 citations in OpenAlex.
- Hormone Replacement Therapy and Cardiovascular Health in Postmenopausal Women.International journal of molecular sciences · 2025Review
- Estrone-mediated lowering of ROS and NOX4 improves endothelial function in ovariectomized wistar rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure.Science advances · 2024Article
- Insights Into the Cardiomodulatory Effects of Sex Hormones: Implications in Transgender Care.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Gender-based research underscores sex differences in biological processes, clinical disorders and pharmacological interventions.Biochemical pharmacology · 2023Review
- Hyperandrogenemia reduces endothelium-derived hyperpolarizing factor-mediated relaxation in mesenteric artery of female rats.Biology of reproduction · 2017Article
- Menopause and Ischemic Stroke: A Brief Review.MOJ toxicology · 2017Article
- Women-specific factors to consider in risk, diagnosis and treatment of cardiovascular disease.Women's health (London, England) · 2015Review
- Endothelial relaxation mechanisms and oxidative stress are restored by atorvastatin therapy in ovariectomized rats.PloS one · 2013Article
- Augmented EDHF signaling in rat uteroplacental vasculature during late pregnancy.American journal of physiology. Heart and circulatory physiology · 2010Article
- Gender differences in the effects of streptozotocin-induced diabetes on parasympathetic vasodilatation in the rat submandibular gland.Archives of oral biology · 2010Article
- Neuroprotection of sex steroids.Minerva endocrinologica · 2010Review
- Estrogen replacement restores flow-induced vasodilation in coronary arterioles of aged and ovariectomized rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- The influence of estrogen and progesterone on parasympathetic vasodilatation in the rat submandibular gland.Autonomic neuroscience : basic & clinical · 2009Article
- Estrogen replacement enhances EDHF-mediated vasodilation of mesenteric and uterine resistance arteries: role of endothelial cell Ca2+.American journal of physiology. Endocrinology and metabolism · 2009Article
- Mechanisms of gender-linked ischemic brain injury.Restorative neurology and neuroscience · 2009Review
- Estrogen, aging and the cardiovascular system.Future cardiology · 2009Review
- Dietary soy modulates endothelium-dependent relaxation in aged male rats: Increased agonist-induced endothelium-derived hyperpolarising factor and basal nitric oxide activity.Free radical biology & medicine · 2006Article
- Nongenomic responses to 17beta-estradiol in male rat mesenteric arteries abolish intrinsic gender differences in vascular responses.British journal of pharmacology · 2005Article
- Reciprocal changes in endothelium-derived hyperpolarizing factor- and nitric oxide-system in the mesenteric artery of adult female rats following ovariectomy.British journal of pharmacology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. We determined whether gender and/or oestrogen deficiency affect endothelium-dependent hyperpolarization and relaxation in mesenteric arteries isolated from middle-aged (44 - 45 week old) rats. 2. The hyperpolarizing response to acetylcholine (ACh) was significantly greater in females than in males. Ovariectomy caused a marked reduction in ACh-induced hyperpolarization in female arteries, and this was improved by 17 beta-oestradiol replacement therapy. 3. ACh-induced relaxations in female arteries were not significantly different from those observed in male rats, and were unaffected by ovariectomy, regardless of whether indomethacin was present. However, when endothelial nitric oxide synthase (eNOS) was blocked with N(G)-nitro-L-arginine, the sensitivity and maximum relaxant response to ACh was significantly higher in intact females compared with males and ovariectomized females. Treatment with 17 beta-oestradiol prevented the reduced vasorelaxant response in ovariectomized females. 4. Immunohistochemical examination for eNOS showed no apparent difference in eNOS protein expression in the endothelium of arteries between intact and ovariectomized females. 5. Since circulating concentrations of oestrogen were essentially low in middle-aged female rats, the present results suggest that subtle changes from a critical concentration of oestrogen at this age may strongly affect the vascular actions of endothelium-derived hyperpolarizing factor without effect on eNOS expression and activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.