ArticleMolecular and cellular biology2002
RAD1 controls the meiotic expansion of the human HRAS1 minisatellite in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- A Whole Genome Screen for Minisatellite Stability Genes in Stationary-Phase Yeast Cells.G3 (Bethesda, Md.) · 2013Article
- The role of CSM3, MRC1, and TOF1 in minisatellite stability and large loop DNA repair during meiosis in yeast.Fungal genetics and biology : FG & B · 2013Article
- Novel checkpoint pathway organization promotes genome stability in stationary-phase yeast cells.Molecular and cellular biology · 2013Article
- Multiple pathways regulate minisatellite stability during stationary phase in yeast.G3 (Bethesda, Md.) · 2012Article
- Stimulation of gross chromosomal rearrangements by the human CEB1 and CEB25 minisatellites in Saccharomyces cerevisiae depends on G-quadruplexes or Cdc13.PLoS genetics · 2012Article
- Minisatellite alterations in ZRT1 mutants occur via RAD52-dependent and RAD52-independent mechanisms in quiescent stationary phase yeast cells.DNA repair · 2011Article
- The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo.PLoS genetics · 2009Article
- Comparative genomics and molecular dynamics of DNA repeats in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2008Review
- Zinc regulates the stability of repetitive minisatellite DNA tracts during stationary phase.Genetics · 2007Article
- Complex minisatellite rearrangements generated in the total or partial absence of Rad27/hFEN1 activity occur in a single generation and are Rad51 and Rad52 dependent.Molecular and cellular biology · 2006Article
- The large loop repair and mismatch repair pathways of Saccharomyces cerevisiae act on distinct substrates during meiosis.Genetics · 2005Article
- Length and sequence heterozygosity differentially affect HRAS1 minisatellite stability during meiosis in yeast.Genetics · 2005Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Minisatellite DNA is repetitive DNA with a repeat unit length from 15 to 100 bp. While stable during mitosis, it destabilizes during meiosis, altering both in length and in sequence composition. The basis for this instability is unknown. To investigate the factors controlling minisatellite stability, a minisatellite sequence 3' of the human HRAS1 gene was introduced into the Saccharomyces cerevisiae genome, replacing the wild-type HIS4 promoter. The minisatellite tract exhibited the same phenotypes in yeast that it exhibited in mammalian systems. The insertion stimulated transcription of the HIS4 gene; mRNA production was detected at levels above those seen with the wild-type promoter. The insertion stimulated meiotic recombination and created a hot spot for initiation of double-strand breaks during meiosis in the regions immediately flanking the repetitive DNA. The tract length altered at a high frequency during meiosis, and both expansions and contractions in length were detected. Tract expansion, but not contraction, was controlled by the product of the RAD1 gene. RAD1 is the first gene identified that controls specifically the expansion of minisatellite tracts. A model for tract length alteration based on these results is presented.
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