ArticleMolecular and cellular biology2002
Structurally normal corneas in aldehyde dehydrogenase 3a1-deficient mice.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Understanding coenzyme Q.Physiological reviews · 2024Review
- Aldehyde Dehydrogenase and Aldo-Keto Reductase Enzymes: Basic Concepts and Emerging Roles in Diabetic Retinopathy.Antioxidants (Basel, Switzerland) · 2023Review
- Identification of a peptide ligand for human ALDH3A1 through peptide phage display: Prediction and characterization of protein interaction sites and inhibition of ALDH3A1 enzymatic activity.Frontiers in molecular biosciences · 2023Article
- Analysis and comparison of tear protein profiles in dogs using different tear collection methods.BMC veterinary research · 2022Article
- Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype.PNAS nexus · 2022Article
- Composition, structure and function of the corneal stroma.Experimental eye research · 2020Review
- Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Cellular and extracellular matrix modulation of corneal stromal opacity.Experimental eye research · 2014Review
- Physiological expression of lens α-, β-, and γ-crystallins in murine and human corneas.Molecular vision · 2010Article
- Corneal aldehyde dehydrogenases: multiple functions and novel nuclear localization.Brain research bulletin · 2010Article
- Differential expression patterns and developmental roles of duplicated scinderin-like genes in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- 4-HNE inhibits tube formation and up-regulates chondromodulin-I in human endothelial cells.Biochemical and biophysical research communications · 2009Article
- Identification of candidate Klf4 target genes reveals the molecular basis of the diverse regulatory roles of Klf4 in the mouse cornea.Investigative ophthalmology & visual science · 2008Article
- Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.Expert opinion on drug metabolism & toxicology · 2008Review
- Corneal crystallins and the development of cellular transparency.Seminars in cell & developmental biology · 2008Review
- The transparent lens and cornea in the mouse and zebra fish eye.Seminars in cell & developmental biology · 2008Review
- Duplicated gelsolin family genes in zebrafish: a novel scinderin-like gene (scinla) encodes the major corneal crystallin.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2007Article
- Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice.The Journal of biological chemistry · 2007Article
- Abundant corneal gelsolin in Zebrafish and the 'four-eyed' fish, Anableps anableps: possible analogy with multifunctional lens crystallins.Experimental eye research · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
We have constructed an ALDH3a1 null mouse to investigate the role of this enzyme that comprises nearly one-half of the total water-soluble protein in the mouse corneal epithelium. ALDH3a1-deficient mice are viable and fertile, have a corneal epithelium with a water-soluble protein content approximately half that of wild-type mice, and contain no ALDH3a1 as determined by zymograms and immunoblots. Despite the loss of protein content and ALDH3a1 activity, the ALDH3a1(-/-) mouse corneas appear indistinguishable from wild-type corneas when examined by histological analysis and electron microscopy and are transparent as determined by light and slit lamp microscopy. There is no evidence for a compensating protein or enzyme. Even though the function of ALDH3a1 in the mouse cornea remains unknown, our data indicate that its enzymatic activity is unnecessary for corneal clarity and maintenance, at least under laboratory conditions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.