Evidence map›Paper›PMID 11784631›Full record

ArticleLancet (London, England)

Blood-pressure reduction and cardiovascular risk in HOPE study.

P Sleight, S Yusuf, J Pogue, R Tsuyuki, R Diaz, J Probstfield, Heart Outcomes Prevention Evaluation (HOPE) Study

Abstract readLetter
PubMed Publisher
In one paragraph

Article in Lancet (London, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 12 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 12 syntheses or guidelines pooled it, 219 citations in OpenAlex.

  1. Pooled it
  2. Antioxidants for adults with chronic kidney disease.The Cochrane database of systematic reviews · 2023
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  7. Effects of milk proteins on blood pressure: a meta-analysis of randomized control trials.Hypertension research : official journal of the Japanese Society of Hypertension · 2017
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  10. Antihypertensive agents for preventing diabetic kidney disease.The Cochrane database of systematic reviews · 2012
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

P SleightDepartment of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK. peter.sleight@attglobal.net
S Yusuf
J Pogue
R Tsuyuki
R Diaz
J Probstfield
Heart Outcomes Prevention Evaluation (HOPE) Study
Fred Hutch Cancer Center · USHamilton General Hospital · CAInstituto Cardiovascular de Rosario · ARJohn Radcliffe Hospital · GBMcMaster University · CAUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the Heart Outcomes Prevention Evaluation (HOPE) study, use of the angiotensin-converting-enzyme inhibitor ramipril was associated with a 22% relative risk reduction in cardiovascular death, myocardial infarction, or stroke, despite only a modest reduction in blood pressure (23.3 mm Hg systolic). To test the hypothesis that the benefits seen were not due to reduced blood pressure alone, we calculated blood-pressure-related risk estimates from the placebo group of the HOPE trial, and from earlier studies. We found that the benefits seen in HOPE were around three times greater than predicted from these calculations. In this well treated and largely normotensive population with coronary disease, but good left-ventricular function, the benefits from ramipril were additive to other proven therapies in normotensive patients and in those with higher baseline blood pressure.

Indexed as

Angiotensin-Converting Enzyme InhibitorsBlood PressureCardiovascular DiseasesHumansRamiprilRisk AssessmentTreatment OutcomeAngiotensin-Converting Enzyme InhibitorsRamipril

Identifiers

PMID11784631
OpenAlexW2125442778

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.