ArticleThe EMBO journal2002
In vivo RNA-directed transcription, with template switching, by a mammalian RNA polymerase.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Hepatitis Delta Virus Genome RNA Synthesis Initiates at Position 1646 with a Nontemplated Guanosine.Journal of virology · 2022Article
- Adaptive Immune Responses, Immune Escape and Immune-Mediated Pathogenesis during HDV Infection.Viruses · 2022Review
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- Hepatitis Delta Antigen Regulates mRNA and Antigenome RNA Levels during Hepatitis Delta Virus Replication.Journal of virology · 2019Article
- Article
- Hepatitis D Virus Replication.Cold Spring Harbor perspectives in medicine · 2015Review
- Hepatitis delta virus: a peculiar virus.Advances in virology · 2013Review
- Article
- 8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress.Free radical biology & medicine · 2010Article
- Origin of hepatitis delta virus.Future microbiology · 2010Review
- Phosphorylation of serine 177 of the small hepatitis delta antigen regulates viral antigenomic RNA replication by interacting with the processive RNA polymerase II.Journal of virology · 2010Article
- Nucleolar targeting of hepatitis delta antigen abolishes its ability to initiate viral antigenomic RNA replication.Journal of virology · 2008Article
- Transcriptional bypass of bulky DNA lesions causes new mutant RNA transcripts in human cells.EMBO reports · 2007Article
- Transport of sequence-specific RNA interference information between cells.Annual review of genetics · 2007Review
- Tertiary structural and functional analyses of a viroid RNA motif by isostericity matrix and mutagenesis reveal its essential role in replication.Journal of virology · 2006Article
- Restoration in vivo of defective hepatitis delta virus RNA genomes.RNA (New York, N.Y.) · 2006Article
- Evolution of hepatitis delta virus RNA genome following long-term replication in cell culture.Journal of virology · 2005Article
- A short double-stranded RNA motif of Peach latent mosaic viroid contains the initiation and the self-cleavage sites of both polarity strands.Journal of virology · 2005Article
- "Defective" mutations of hepatitis D viruses in chronic hepatitis D patients.World journal of gastroenterology · 2005Article
- RNA recombination of hepatitis delta virus in natural mixed-genotype infection and transfected cultured cells.Journal of virology · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
These studies support the interpretation that a host polymerase, most likely RNA polymerase II, can not only carry out transcription that is RNA directed, but also achieve template switching on a discontinuous RNA template, and even perform non-templated nucleotide incorporation. As part of an in vivo analysis of the initiation of replication of the RNA genome of human hepatitis delta virus (HDV), a series of linear RNAs containing HDV sequences was tested in order to explain the ability of this host polymerase to initiate RNA-directed RNA synthesis in vivo and produce replicating circular HDV species. The data support the hypothesis that the input linear template RNAs were not converted to circles before transcription but rather that in the process of transcription, the polymerase was able to make an intra-molecular template switch. Furthermore, in certain cases this switch produced small deletions of template sequences, and in some cases even insertion of non-templated sequences. Thus, in an in vivo situation, polymerase II has several important capabilities in addition to what is considered typical DNA-directed transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.