ArticleThe EMBO journal2002
IL-7Ralpha and E47: independent pathways required for development of multipotent lymphoid progenitors.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 60 citations in OpenAlex.
- Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T-ALL.Leukemia · 2024Article
- Helix-Loop-Helix Proteins in Adaptive Immune Development.Frontiers in immunology · 2022Review
- Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.Haematologica · 2017Article
- Flt3 signaling regulates the proliferation, survival, and maintenance of multipotent hematopoietic progenitors that generate B cell precursors.Experimental hematology · 2014Article
- E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment.Blood · 2013Article
- Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis.Biochemical and biophysical research communications · 2012Article
- Aging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues.Aging and disease · 2011Article
- Age effects on B cells and humoral immunity in humans.Ageing research reviews · 2011Review
- Mtg16/Eto2 contributes to murine T-cell development.Molecular and cellular biology · 2011Article
- Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci.The Journal of experimental medicine · 2009Article
- Effects of fenbendazole on the murine humoral immune system.Journal of the American Association for Laboratory Animal Science : JAALAS · 2009Article
- The effects of c-Abl mutation on developing B cell differentiation and survival.International immunology · 2009Article
- E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene.European journal of immunology · 2008Article
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- The ontogeny and fate of NK cells marked by permanent DNA rearrangements.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Extrinsic and intrinsic regulation of early natural killer cell development.Immunologic research · 2008Review
- Basic helix-loop-helix protein E47-mediated p21Waf1/Cip1 gene expression regulates apoptosis of intestinal epithelial cells.The Biochemical journal · 2007Article
- E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- E47 is required for V(D)J recombinase activity in common lymphoid progenitors.The Journal of experimental medicine · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice that lack the transcription factors encoded by the E2A gene or the receptor for interleukin 7 (IL-7R) have severe overlapping defects in lymphocyte development. Here, we show that E2A proteins are required for the survival of early T-lineage cells; however, they function through a pathway that is distinct from the survival pathway initiated by IL-7R signaling. While E2A proteins are required to suppress caspase 3 activation, ectopic expression of the anti-apoptotic protein Bcl-2 is not sufficient to overcome the lymphopoietic defects observed in the absence of E2A. Remarkably, mice that lack both IL-7Ralpha and E47 display a synergistic decrease in the number of T-cell, NK-cell and multipotent progenitors in the thymus, indicating that these distinct survival pathways converge to promote the development of multipotent lymphoid progenitors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.