ArticleThe EMBO journal2002
Plasmodium falciparum activates endogenous Cl(-) channels of human erythrocytes by membrane oxidation.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Apoptosis and eryptosis: similarities and differences.Apoptosis : an international journal on programmed cell death · 2024Review
- Epigenetics of malaria parasite nutrient uptake, but why?Trends in parasitology · 2022Review
- Role of Eryptosis in Hemorrhagic Stroke.Frontiers in molecular neuroscience · 2022Review
- Article
- The Chloride Conductance Inhibitor NS3623 Enhances the Activity of a Non-selective Cation Channel in Hyperpolarizing Conditions.Frontiers in physiology · 2021Article
- Ion Transport in Eryptosis, the Suicidal Death of Erythrocytes.Frontiers in cell and developmental biology · 2020Review
- Targeting Channels and Transporters in Protozoan Parasite Infections.Frontiers in chemistry · 2018Review
- The influence of host genetics on erythrocytes and malaria infection: is there therapeutic potential?Malaria journal · 2015Review
- Channelizing the red blood cell: molecular biology competes with patch-clamp.Frontiers in molecular biosciences · 2015Article
- Triggers, inhibitors, mechanisms, and significance of eryptosis: the suicidal erythrocyte death.BioMed research international · 2015Review
- Regulation of extracellular ATP in human erythrocytes infected with Plasmodium falciparum.PloS one · 2014Article
- Article
- Oxidative stress in malaria.International journal of molecular sciences · 2012Review
- Decreased redox-sensitive erythrocyte cation channel activity in aquaporin 9-deficient mice.The Journal of membrane biology · 2012Article
- Anti-malarial effect of gum arabic.Malaria journal · 2011Article
- Infection by Trypanosoma cruzi enhances anion conductance in rat neonatal ventricular cardiomyocytes.The Journal of membrane biology · 2010Article
- Beneficial effect of aurothiomalate on murine malaria.Malaria journal · 2010Article
- The malaria parasite Plasmodium falciparum: cell biological peculiarities and nutritional consequences.Protoplasma · 2010Review
- Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human equilibrative nucleoside transporter and the human facilitative nucleobase transporter.Malaria journal · 2010Article
- The survival strategies of malaria parasite in the red blood cell and host cell polymorphisms.Malaria research and treatment · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intraerythrocytic survival of the malaria parasite Plasmodium falciparum requires that host cells supply nutrients and dispose of waste products. This solute transport is accomplished by infection-induced new permeability pathways (NPP) in the erythrocyte membrane. Here, whole-cell patch-clamp and hemolysis experiments were performed to define properties of the NPP. Parasitized but not control erythrocytes constitutively expressed two types of anion conductances, differing in voltage dependence and sensitivity to inhibitors. In addition, infected but not control cells hemolyzed in isosmotic sorbitol solution. Both conductances and hemolysis of infected cells were inhibited by reducing agents. Conversely, oxidation induced identical conductances and hemolysis in non-infected erythrocytes. In conclusion, P.falciparum activates endogenous erythrocyte channels by applying oxidative stress to the host cell membrane.
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Registered trials
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