ArticleOncogene2001
Neural precursor cell apoptosis and glial tumorigenesis following transplacental ethyl-nitrosourea exposure.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Injury primes mutation-bearing astrocytes for dedifferentiation in later life.Current biology : CB · 2023Article
- The Subventricular Zone in Glioblastoma: Genesis, Maintenance, and Modeling.Frontiers in oncology · 2022Review
- Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications.Frontiers in oncology · 2019Review
- The subventricular zone is able to respond to a demyelinating lesion after localized radiation.Stem cells (Dayton, Ohio) · 2014Article
- The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche.Molecular and cellular biology · 2012Article
- Exposure to N-ethyl-N-nitrosourea in adult mice alters structural and functional integrity of neurogenic sites.PloS one · 2012Article
- Primary brain tumors, neural stem cell, and brain tumor cancer cells: where is the link?Neuropharmacology · 2010Review
- Wnt/beta-catenin/Tcf signaling pathway activation in malignant progression of rat gliomas induced by transplacental N-ethyl-N-nitrosourea exposure.Neurochemical research · 2009Article
- Article
- Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2008Review
- Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Loss of GFAP expression in high-grade astrocytomas does not contribute to tumor development or progression.Oncogene · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Neural precursor cells (NPCs) populate the embryonic ventricular zone and persist in the subependymal zone of the adult brain. We hypothesized that hereditary and/or acquired mutations in apoptosis-associated genes, such as p53 and caspases, may protect NPCs from DNA damage-induced death and predispose them to subsequent neoplastic transformation. To test this hypothesis, we exposed NPCs from wild-type and targeted gene-disrupted mouse embryos (p53, caspase-9, caspase-3, and bax mutants) to ethyl-nitrosourea (ENU), a known DNA mutagen and neural carcinogen, and measured NPC viability. We found that ENU produced caspase-3 activation and apoptotic NPC death 6-24 h after administration both in vivo and in vitro. This effect was critically dependent on p53 and caspase-9 expression. The long-term effect of intrauterine ENU exposure was examined in control and p53-deficient mice. High grade glial tumors were found in 60% of p53(-/-) young adult mice exposed to ENU on gestational day 12.5 but not in p53(+/-) or p53(+/+) littermates or in untreated p53-deficient mice. All the tumors were located supratentorially and possessed strong immunoreactivity for glial fibrillary acidic protein and the anti-apoptotic molecule Bcl-X(L). These results suggest that intrauterine exposure of NPCs to certain DNA damaging agents may synergistically interact with specific genetic abnormalities (e.g. p53 deficiency) to produce glial neoplasms in the adult brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.