ArticleOncogene2001
Recruitment of TRRAP required for oncogenic transformation by E1A.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 83 citations in OpenAlex.
- Adenovirus small E1A directs activation of Alu transcription at YAP/TEAD- and AP-1-bound enhancers through interactions with the EP400 chromatin remodeler.Nucleic acids research · 2024Article
- The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells.eLife · 2022Article
- Prospects for pharmacological targeting of pseudokinases.Nature reviews. Drug discovery · 2019Review
- Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes.Transcription · 2019Review
- Review
- Article
- Article
- Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution.eLife · 2017Article
- Article
- The adenoviral E1A N-terminal domain represses MYC transcription in human cancer cells by targeting both p300 and TRRAP and inhibiting MYC promoter acetylation of H3K18 and H4K16.Genes & cancer · 2016Article
- The Cellular Protein Complex Associated with a Transforming Region of E1A Contains c-MYC.Journal of virology · 2016Article
- SGF29 and Sry pathway in hepatocarcinogenesis.World journal of biological chemistry · 2015Review
- SETD6 controls the expression of estrogen-responsive genes and proliferation of breast carcinoma cells.Epigenetics · 2014Article
- ATP-dependent chromatin remodeling complexes as novel targets for cancer therapy.Advances in cancer research · 2014Review
- Functional similarity between E6 proteins of cutaneous human papillomaviruses and the adenovirus E1A tumor-restraining module.Journal of virology · 2013Article
- Opposing oncogenic activities of small DNA tumor virus transforming proteins.Trends in microbiology · 2011Review
- Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes.Molecular and cellular biology · 2011Article
- Distinct regulatory mechanisms of eukaryotic transcriptional activation by SAGA and TFIID.Biochimica et biophysica acta · 2011Review
- E1A interacts with two opposing transcriptional pathways to induce quiescent cells into S phase.Journal of virology · 2010Article
- Adenovirus type 5 E1A and E6 proteins of low-risk cutaneous beta-human papillomaviruses suppress cell transformation through interaction with FOXK1/K2 transcription factors.Journal of virology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TRRAP links Myc with histone acetylases and appears to be an important mediator of its oncogenic function. Here we show that interaction with TRRAP is required for cellular transformation not only by Myc, but also by the adenovirus E1A protein. Substitution of the 262 N-terminal residues of Myc with a small domain of E1A (residues 12-54) restores Myc transforming function. E1A(12-54) contains a TRRAP-interaction domain, that recruits TRRAP to either E1A-Myc chimeras, or the native 12S E1A protein. Overexpression of a competing TRRAP fragment in vivo blocks interaction of cellular TRRAP with either E1A-Myc or E1A, and suppresses cellular transformation by both oncoproteins. Moreover, E1A(Delta26-35) that fails to bind TRRAP but is capable of binding the Retinoblastoma (Rb)-family and p300/CBP proteins is defective in cellular immortalization, transformation and cell cycle deregulation. Thus in addition to disrupting Rb and p300/CBP functions, E1A must recruit TRRAP to transform cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.