ArticleThe Journal of experimental medicine2002
Dendritic cells pulsed with intact Streptococcus pneumoniae elicit both protein- and polysaccharide-specific immunoglobulin isotype responses in vivo through distinct mechanisms.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 139 citations in OpenAlex.
- Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness?Frontiers in immunology · 2018Review
- T cells control the generation of nanomolar-affinity anti-glycan antibodies.The Journal of clinical investigation · 2017Article
- Dendritic cell-based immunotherapy.Cell research · 2017Review
- The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.The Journal of experimental medicine · 2016Article
- Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.Mucosal immunology · 2016Article
- Bright fluorescent Streptococcus pneumoniae for live-cell imaging of host-pathogen interactions.Journal of bacteriology · 2015Article
- Noncovalent association of protein and capsular polysaccharide on bacteria-sized latex beads as a model for polysaccharide-specific humoral immunity to intact gram-positive extracellular bacteria.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Pentraxins: structure, function, and role in inflammation.ISRN inflammation · 2013Review
- Copresentation of intact and processed MHC alloantigen by recipient dendritic cells enables delivery of linked help to alloreactive CD8 T cells by indirect-pathway CD4 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes.Nature reviews. Immunology · 2013Review
- Prenatal cadmium exposure produces persistent changes to thymus and spleen cell phenotypic repertoire as well as the acquired immune response.Toxicology and applied pharmacology · 2012Article
- Regulation of frontline antibody responses by innate immune signals.Immunologic research · 2012Review
- Bone marrow dendritic cell-mediated regulation of TLR and B cell receptor signaling in B cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Activation of B cells by non-canonical helper signals.EMBO reports · 2012Review
- New helping friends for B cells.European journal of immunology · 2012Review
- Differential idiotype utilization for the in vivo type 14 capsular polysaccharide-specific Ig responses to intact Streptococcus pneumoniae versus a pneumococcal conjugate vaccine.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Prenatal cadmium exposure alters postnatal immune cell development and function.Toxicology and applied pharmacology · 2012Article
- Role of p47phox in antigen-presenting cell-mediated regulation of humoral immunity in mice.The American journal of pathology · 2011Article
- Identification of CD4+ T cell epitopes in C. burnetii antigens targeted by antibody responses.PloS one · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Immature bone marrow-derived myeloid dendritic cells (BMDCs) are induced to undergo phenotypic maturation and secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-12, and IL-10 when pulsed in vitro with intact Streptococcus pneumoniae. After transfer to naive mice, pulsed BMDCs induce immunoglobulin (Ig) isotype responses specific for both protein and polysaccharide pneumococcal antigens, having in common the requirement for viable BMDCs, T cells, and B7-dependent costimulation in the recipient mice. Whereas primary Ig isotype responses to bacterial proteins uniformly require BMDC expression of major histocompatibility complex class II, CD40, and B7, and the secretion of IL-6, but not IL-12, similar requirements for antipolysaccharide Ig responses were only observed for the IgG1 isotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.