ArticleThe Journal of cell biology2002
The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 87 citations in OpenAlex.
- An explorative cross-sectional study on the association between immunological biomarkers in patients with chronic pain.Brain, behavior, & immunity - health · 2026Article
- Aqueous Humor Cytokines in Idiopathic Epiretinal Membrane: Correlation with Disease Severity.Diagnostics (Basel, Switzerland) · 2024Article
- Effects of house-cultivated edible bird's nest on immunoglobulin and cytokine releaseVeterinary world · 2024Article
- Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing-Fantasy or reality?Chronic diseases and translational medicine · 2023Review
- Green Synthesis of Gold Nanoparticles with Curcumin or Açai in the Tissue Repair of Palatal Wounds.Antioxidants (Basel, Switzerland) · 2023Article
- Are There Differences in Inflammatory and Fibrotic Pathways between IPAF, CTD-ILDs, and IIPs? A Single-Center Pilot Study.International journal of molecular sciences · 2022Observational
- Proteomic profiling reveals engineered chitosan nanoparticles mediated cellular crosstalk and immunomodulation for therapeutic application in apical periodontitis.Bioactive materials · 2022Article
- HB-EGF-induced IL-8 secretion from airway epithelium leads to lung fibroblast proliferation and migration.BMC pulmonary medicine · 2021Article
- Article
- Evaluation of clinical, histological, TNF-α, and collagen expressions on oral ulcer in rats after treatment withF1000Research · 2021Article
- Chemokine Involvement in Fetal and Adult Wound Healing.Advances in wound care · 2015Review
- Effect of silk fibroin nanofibers containing silver sulfadiazine on wound healing.International journal of nanomedicine · 2014Article
- Chemokines and Their Receptors Are Key Players in the Orchestra That Regulates Wound Healing.Advances in wound care · 2013Review
- Two types of nanoparticle-based bio-barcode amplification assays to detect HIV-1 p24 antigen.Virology journal · 2012Article
- A new hypothesis for the cancer mechanism.Cancer metastasis reviews · 2012Review
- Nanohybrids of silver particles immobilized on silicate platelet for infected wound healing.PloS one · 2012Article
- Silver nanoparticles as real topical bullets for wound healing.The journal of the American College of Clinical Wound Specialists · 2011Review
- Recent advances in underlying pathologies provide insight into interleukin-8 expression-mediated inflammation and angiogenesis.International journal of inflammation · 2011Article
- The functional behavior of a macrophage/fibroblast co-culture model derived from normal and diabetic mice with a marine gelatin-oxidized alginate hydrogel.Biomaterials · 2010Article
- A soluble factor (EMMPRIN) in exudate influences knee motion after total arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Chemokines are small cytokines primarily known for their roles in inflammation. More recently, however, they have been implicated in processes involved in development of the granulation tissue of wounds, but little is known about their functions during this process. Fibroblasts play key roles in this phase of healing: some fibroblasts differentiate into myofibroblasts, alpha-smooth muscle actin (SMA)-producing cells that are important in wound closure and contraction. Here we show that the CXC chemokine chicken chemotactic and angiogenic factor (cCAF) stimulates fibroblasts to produce high levels of alpha-SMA and to contract collagen gels more effectively than do normal fibroblasts, both characteristic properties of myofibroblasts. Specific inhibition of alpha-SMA expression resulted in abrogation of cCAF-induced contraction. Furthermore, application of cCAF to wounds in vivo increases the number of myofibroblasts present in the granulation tissue and accelerates wound closure and contraction. We also show that these effects in culture and in vivo can be achieved by a peptide containing the NH2-terminal 15 amino acids of the cCAF protein and that inhibition of alpha-SMA expression also results in inhibition of N-peptide-induced collagen gel contraction. We propose that chemokines are major contributors for the differentiation of fibroblasts into myofibroblasts during formation of the repair tissue. Because myofibroblasts are important in many pathological conditions, and because chemokines and their receptors are amenable to pharmacological manipulations, chemokine stimulation of myofibroblast differentiation may have implications for modulation of functions of these cells in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.