ArticleRNA (New York, N.Y.)2001
The specificity of nucleotide removal during RNA editing in Trypanosoma brucei.
Article in RNA (New York, N.Y.), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing.Science (New York, N.Y.) · 2023Article
- Cell-line specific RNA editing patterns in Trypanosoma brucei suggest a unique mechanism to generate protein variation in a system intolerant to genetic mutations.Nucleic acids research · 2020Article
- Trypanosoma brucei ATPase subunit 6 mRNA bound to gA6-14 forms a conserved three-helical structure.RNA (New York, N.Y.) · 2008Article
- Trypanosoma brucei RNA editing: coupled cycles of U deletion reveal processive activity of the editing complex.Molecular and cellular biology · 2008Article
- RNA editing in Trypanosoma brucei requires three different editosomes.Molecular and cellular biology · 2008Article
- Reconstitution of full-round uridine-deletion RNA editing with three recombinant proteins.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- An essential RNase III insertion editing endonuclease in Trypanosoma brucei.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Minimal pre-mRNA substrates with natural and converted sites for full-round U insertion and U deletion RNA editing in trypanosomes.Nucleic acids research · 2005Article
- Comparative analysis of editosome proteins in trypanosomatids.Nucleic acids research · 2003Article
- Uridine insertion/deletion RNA editing in trypanosome mitochondria: a complex business.RNA (New York, N.Y.) · 2003Review
- RNA sequence and base pairing effects on insertion editing in Trypanosoma brucei.Molecular and cellular biology · 2002Article
- Role of uridylate-specific exoribonuclease activity in Trypanosoma brucei RNA editing.Eukaryotic cell · 2002Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
RNA editing in Trypanosoma brucei produces mature mRNAs by posttranscriptional insertion and deletion of uridylates (Us) by a series of catalytic steps, which include endoribonucleolytic cleavage, 3' terminal addition or removal of Us, and RNA ligation. Preedited mRNA (pre-mRNA) and guide RNA (gRNA) that are mutated at or near the editing site (ES) were used to examine the effects on the specificity of in vitro editing. Sequences that are not predicted to form a gRNA/pre-mRNA base pair immediately 5' to the ES still supported accurate editing. Substitution of a non-U nucleotide at various positions within a stretch of Us that are normally removed from the ES resulted in deletion of only the Us that were 3' to the substituted nucleotide. Overall, ES selection by the endoribonuclease, the specificity of the 3' exoribonuclease for Us, and ligation appear to act in concert to ensure the production of accurately edited RNA.
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Registered trials
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