ArticleGenome research2002
A comparative genomic analysis of two distant diptera, the fruit fly, Drosophila melanogaster, and the malaria mosquito, Anopheles gambiae.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 67 citations in OpenAlex.
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- General control nonderepressible 1 interacts with cationic amino acid transporter 1 and affects Aedes aegypti fecundity.Parasites & vectors · 2022Article
- Assembly-free rapid differential gene expression analysis in non-model organisms using DNA-protein alignment.BMC genomics · 2022Article
- A High-Quality Genome Assembly from Short and Long Reads for the Non-biting MidgeG3 (Bethesda, Md.) · 2020Article
- The genomic features of parasitism, Polyembryony and immune evasion in the endoparasitic wasp Macrocentrus cingulum.BMC genomics · 2018Article
- Irregular designs and Darwinism in biology: Genomes as the test case.Journal of biosciences · 2017Article
- Evidence for parallel evolution of a gene involved in the regulation of spermatogenesis.Proceedings. Biological sciences · 2017Article
- Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation.PLoS genetics · 2016Article
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- Linkage disequilibrium network analysis (LDna) gives a global view of chromosomal inversions, local adaptation and geographic structure.Molecular ecology resources · 2015Article
- New microRNAs in Drosophila--birth, death and cycles of adaptive evolution.PLoS genetics · 2014Article
- Linkage map of the peppered moth, Biston betularia (Lepidoptera, Geometridae): a model of industrial melanism.Heredity · 2013Article
- Conserved boundary elements from the Hox complex of mosquito, Anopheles gambiae.Nucleic acids research · 2013Article
- Chromosomal organization at the level of gene complexes.Cellular and molecular life sciences : CMLS · 2011Review
- Isolation, annotation and applications of expressed sequence tags from the olive fly, Bactrocera oleae.Molecular genetics and genomics : MGG · 2011Article
- Evolving enhancer-promoter interactions within the tinman complex of the flour beetle, Tribolium castaneum.Development (Cambridge, England) · 2009Article
- Molecular evolution of the testis TAFs of Drosophila.Molecular biology and evolution · 2009Article
- Conserved cluster organization of insect Runx genes.Development genes and evolution · 2008Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome evolution entails changes in the DNA sequence of genes and intergenic regions, changes in gene numbers, and also changes in gene order along the chromosomes. Genes are reshuffled by chromosomal rearrangements such as deletions/insertions, inversions, translocations, and transpositions. Here we report a comparative study of genome organization in the main African malaria vector, Anopheles gambiae, relative to the recently determined sequence of the Drosophila melanogaster genome. The ancestral lines of these two dipteran insects are thought to have separated approximately 250 Myr, a long period that makes this genome comparison especially interesting. Sequence comparisons have identified 113 pairs of putative orthologs of the two species. Chromosomal mapping of orthologous genes reveals that each polytene chromosome arm has a homolog in the other species. Between 41% and 73% of the known orthologous genes remain linked in the respective homologous chromosomal arms, with the remainder translocated to various nonhomologous arms. Within homologous arms, gene order is extensively reshuffled, but a limited degree of conserved local synteny (microsynteny) can be recognized.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.