ArticleGenetics2001
Two-locus sampling distributions and their application.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 253 papers.
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Who cites it
253 citing papers in PubMed.
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- Tree Sequences as a General-Purpose Tool for Population Genetic Inference.Molecular biology and evolution · 2024Article
- Tree sequences as a general-purpose tool for population genetic inference.bioRxiv : the preprint server for biology · 2024Article
- Joint identity among loci under mutation and regular inbreeding.Theoretical population biology · 2024Article
- Linkage equilibrium between rare mutations.bioRxiv : the preprint server for biology · 2024Article
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- Rhometa: Population recombination rate estimation from metagenomic read datasets.PLoS genetics · 2023Article
- Bee Trypanosomatids: First Steps in the Analysis of the Genetic Variation and Population Structure of Lotmaria passim, Crithidia bombi and Crithidia mellificae.Microbial ecology · 2022Article
- Local fitness and epistatic effects lead to distinct patterns of linkage disequilibrium in protein-coding genes.Genetics · 2022Article
- Recombination landscape divergence between populations is marked by larger low-recombining regions in domesticated rye.Molecular biology and evolution · 2022Article
- Properties of 2-locus genealogies and linkage disequilibrium in temporally structured samples.Genetics · 2022Article
- Fine human genetic map based on UK10K data set.Human genetics · 2022Article
- Genealogical structure changes as range expansions transition from pushed to pulled.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Interspecies Recombination Has Driven the Macroevolution of Cassava Mosaic Begomoviruses.Journal of virology · 2021Article
- Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome.PLoS genetics · 2021Article
193 more citing papers are in PubMed but not listed here.
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Abstract
Methods of estimating two-locus sample probabilities under a neutral model are extended in several ways. Estimation of sample probabilities is described when the ancestral or derived status of each allele is specified. In addition, probabilities for two-locus diploid samples are provided. A method for using these two-locus probabilities to test whether an observed level of linkage disequilibrium is unusually large or small is described. In addition, properties of a maximum-likelihood estimator of the recombination parameter based on independent linked pairs of sites are obtained. A composite-likelihood estimator, for more than two linked sites, is also examined and found to work as well, or better, than other available ad hoc estimators. Linkage disequilibrium in the Xq28 and Xq25 region of humans is analyzed in a sample of Europeans (CEPH). The estimated recombination parameter is about five times smaller than one would expect under an equilibrium neutral model.
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