ArticleGenetics2001
P-Element repression in Drosophila melanogaster by variegating clusters of P-lacZ-white transgenes.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- Adaptive P-element Insertions in a Long Non-Coding RNA are Potential Emerging piRNA Clusters.Genome biology and evolution · 2026Article
- Article
- Mechanism and regulation of P element transposition.Open biology · 2020Review
- Article
- A Screening Method for Identification of Heterochromatin-Promoting Drugs Using Drosophila.Journal of visualized experiments : JoVE · 2020Article
- Identification of methotrexate as a heterochromatin-promoting drug.Scientific reports · 2019Article
- Article
- Transposon regulation in Drosophila: piRNA-producing P elements facilitate repression of hybrid dysgenesis by a P element that encodes a repressor polypeptide.Molecular genetics and genomics : MGG · 2015Article
- Epigenetic inheritance of metabolic state.Current opinion in genetics & development · 2014Review
- Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing.Genes & development · 2014Article
- Profiles of piRNA abundances at emerging or established piRNA loci are determined by local DNA sequences.RNA biology · 2013Article
- Article
- Homology-dependent silencing by an exogenous sequence in the Drosophila germline.G3 (Bethesda, Md.) · 2012Article
- Article
- Protein complex of Drosophila ATRX/XNP and HP1a is required for the formation of pericentric beta-heterochromatin in vivo.The Journal of biological chemistry · 2010Article
- Epigenetic transmission of piRNAs through the female germline.Genome biology · 2009Review
- Article
- Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability.Nature cell biology · 2008Article
- Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation.PLoS genetics · 2007Article
- JAK signaling globally counteracts heterochromatic gene silencing.Nature genetics · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila, clusters of P transgenes (P-lac-w) display a variegating phenotype for the w marker. In addition, X-ray-induced rearrangements of chromosomes bearing such clusters may lead to enhancement of the variegated phenotype. Since P-lacZ transgenes in subtelomeric heterochromatin have some P-element repression abilities, we tested whether P-lac-w clusters also have the capacity to repress P-element activity in the germline. One cluster (T-1), located on a rearranged chromosome (T2;3) and derived from a line bearing a variegating tandem array of seven P-lac-w elements, partially represses the dysgenic sterility (GD sterility) induced by P elements. This cluster also strongly represses in trans the expression of P-lacZ elements in the germline. This latter suppression shows a maternal effect. Finally, the combination of variegating P-lac-w clusters and a single P-lacZ reporter inserted in subtelomeric heterochromatic sequences at the X chromosome telomere (cytological site 1A) leads to strong repression of dysgenic sterility. These results show that repression of P-induced dysgenic sterility can be elicited in the absence of P elements encoding a polypeptide repressor and that a transgene cluster can repress the expression of a single homologous transgene at a nonallelic position. Implications for models of transposable element silencing are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.