ArticleAnnals of the Royal College of Surgeons of England2001
Feasibility study of colonoscopy as the primary screening investigation in relatives of patients with colorectal cancer.
Article in Annals of the Royal College of Surgeons of England, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed, 13 citations in OpenAlex.
- 22-year longitudinal study of repetitive colonoscopy in patients with a family history of colorectal cancer.Annals of the Royal College of Surgeons of England · 2013Article
- Preferences for CT colonography and colonoscopy as diagnostic tests for colorectal cancer: a discrete choice experiment.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2011Article
- Symptomatic presentation of early colorectal cancer.Annals of the Royal College of Surgeons of England · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimRelatives of patients with colorectal cancer are thought to be at a higher risk for this disease than the average population. We aimed to determine whether colonoscopy is a feasible primary screening investigation for this group to identify premalignant and malignant lesions.
methodsA total of 449 people underwent colonoscopy and all had one or more relatives with colorectal cancer, of these, 212 were classified as 'asymptomatic' and 237 as being 'symptomatic'. Colonoscopy commenced at 40 years of age or 10 years younger than the youngest affected relative.
resultsNeoplastic change, benign and malignant, was found in 25.5% of the 'asymptomatic' group and 24% of the 'symptomatic' group; in 26% of those with one first degree relative, 39% with two or more first degree relatives and only 19% with second degree relatives. 38% of lesions were out of reach of a flexible sigmoidoscope. No known complications occurred.
conclusionsIt is feasible to perform colonoscopy as the primary investigation for the first degree relatives of patients with colorectal cancer. The yield of neoplastic lesions is sufficient to make this appropriate.
Indexed as
Identifiers
11777138PMC2503678W74290119What OpenQuestion holds
Registered trials
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