Trial reportNeoplasia (New York, N.Y.)
Hypoxia and VEGF mRNA expression in human tumors.
Trial report in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- Study on Factors Associated with High Myopia CNV in Aqueous Humor and Serum.BioMed research international · 2022Article
- Invited editorial for the paper by Silvoniemi et al. "Repeatability of tumor hypoxia imaging using [European journal of nuclear medicine and molecular imaging · 2018Article
- Molecular and functional evaluation of a novel HIF inhibitor, benzopyranyl 1,2,3-triazole compound.Oncotarget · 2017Article
- Role of Extracellular Vesicles in Hematological Malignancies.BioMed research international · 2015Review
- The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities.Antioxidants & redox signaling · 2014Review
- Candidate biomarkers for cervical cancer treatment: Potential for clinical practice (Review).Molecular and clinical oncology · 2014Article
- Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival.Cancer science · 2013Article
- A role for MT1-MMP as a cell death sensor/effector through the regulation of endoplasmic reticulum stress in U87 glioblastoma cells.Journal of neuro-oncology · 2011Article
- In vivo identification and specificity assessment of mRNA markers of hypoxia in human and mouse tumors.BMC cancer · 2011Article
- VEGF deficit is involved in endothelium dysfunction in preeclampsia.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2010Article
- Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors.Radiation research · 2008Article
- Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome.International journal of radiation oncology, biology, physics · 2007Article
- Necrosis induction in glioblastoma cells reveals a new "bioswitch" function for the MT1-MMP/G6PT signaling axis in proMMP-2 activation versus cell death decision.Neoplasia (New York, N.Y.) · 2007Article
- Serum level of vascular endothelial growth factor in patients with obstructive sleep apnea hypopnea syndrome.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2007Article
- Hyperbaric oxygen therapy for malignancy: a review.World journal of surgery · 2006Review
- Plausible linkage of hypoxia inducible factor-1alpha in uterine cervical cancer.Cancer science · 2006Article
- Hepatic artery infusion of antisense oligodeoxynucleotide and lipiodol mixture transfect liver cancer in rats.World journal of gastroenterology · 2005Article
- Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Microenvironmental adaptation of experimental tumours to chronic vs acute hypoxia.British journal of cancer · 2004Article
- Vascular endothelial growth factor (VEGF) in leptomeningeal metastasis: diagnostic and prognostic value.British journal of cancer · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
High expression of circulating plasma vascular endothelial growth factor (VEGF) in patients with cancer is an indicator of poor treatment response. Similarly, hypoxia in tumors, as measured by oxygen needle electrodes, has been found to predict for tumor-treatment failure. These two predictors may be related because hypoxia is a potent stimulator of VEGF expression in vitro. However, the demonstration of a relationship between hypoxia and VEGF in human tumors has, to date, been indirect or even negative. The purpose of this study was to test whether this unexpected result was caused by factors unique to human tumors, or whether the prior results could have been influenced by the known complexities of VEGF regulation. Therefore, we undertook a direct assessment of VEGF induction in human tumors using in situ hybridization and compared its distribution with that of hypoxia, as measured by the distribution of adducts of the hypoxia marker EF5. The distribution of both markers was assessed in relationship to the distribution of blood vessels, as measured by antibodies to CD31. Our hypothesis was that VEGF mRNA and hypoxia would colocalize, assuming that detectability of the former was not limiting. Four squamous cell carcinomas, three sarcomas and one glioblastoma multiforme were studied. When VEGF mRNA signal was detectable, its maxima colocalized with regional maxima of EF5 binding. The strongest levels of both signals were sometimes adjacent to regions of tissue necrosis. However, we were unable to predict absolute levels of EF5 binding based on absolute levels of VEGF mRNA. Conversely, for all tumors studied, regions with relatively low levels of EF5 binding had relatively low or undetectable VEGF mRNA. We found moderate EF5 binding in some keratinized cells but VEGF mRNA was not expressed by these differentiated cells. The paradigm that hypoxia and VEGF expression are linked in human tumors is supported by the data presented herein. A better understanding of the biology behind VEGF expression, including its modulation by hypoxia, is important for optimizing its use as a prognostic indicator and/or modulating its presence with biologic therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.