ArticleJournal of virology2002
Alterations in NF-kappaB and RBP-Jkappa by arenavirus infection of macrophages in vitro and in vivo.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Virulent infection of outbred Hartley guinea pigs with recombinant Pichinde virus as a surrogate small animal model for human Lassa fever.Virulence · 2020Article
- Characterization of the host response to pichinde virus infection in the Syrian golden hamster by species-specific kinome analysis.Molecular & cellular proteomics : MCP · 2015Article
- The role of platelets in the pathogenesis of viral hemorrhagic fevers.PLoS neglected tropical diseases · 2014Review
- Innate immune response to arenaviral infection: a focus on the highly pathogenic New World hemorrhagic arenaviruses.Journal of molecular biology · 2013Review
- Identification of virulence determinants within the L genomic segment of the pichinde arenavirus.Journal of virology · 2013Article
- A systems biology starter kit for arenaviruses.Viruses · 2012Review
- Immune responses and Lassa virus infection.Viruses · 2012Review
- Junín virus pathogenesis and virus replication.Viruses · 2012Review
- Arenavirus evasion of host anti-viral responses.Viruses · 2012Review
- Pathogenic Old World arenaviruses inhibit TLR2/Mal-dependent proinflammatory cytokines in vitro.Journal of virology · 2012Article
- Proteomic analysis of Pichindé virus infection identifies differential expression of prothymosin-alpha.Journal of biomedicine & biotechnology · 2010Article
- Attenuated and lethal variants of Pichindé virus induce differential patterns of NF-kappaB activation suggesting a potential target for novel therapeutics.Viral immunology · 2009Article
- Pichinde virus induces microvascular endothelial cell permeability through the production of nitric oxide.Virology journal · 2009Article
- Molecular determinants of Pichinde virus infection of guinea pigs--a small animal model system for arenaviral hemorrhagic fevers.Annals of the New York Academy of Sciences · 2009Article
- Interleukin-33 is biologically active independently of caspase-1 cleavage.The Journal of biological chemistry · 2009Article
- Development of infectious clones for virulent and avirulent pichinde viruses: a model virus to study arenavirus-induced hemorrhagic fevers.Journal of virology · 2009Article
- Analysis of the differential host cell nuclear proteome induced by attenuated and virulent hemorrhagic arenavirus infection.Journal of virology · 2009Article
- Genome comparison of virulent and avirulent strains of the Pichinde arenavirus.Archives of virology · 2008Article
- Early blood profiles of virus infection in a monkey model for Lassa fever.Journal of virology · 2007Article
- Identification of differentially activated cell-signaling networks associated with pichinde virus pathogenesis by using systems kinomics.Journal of virology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pichinde virus is an arenavirus that infects guinea pigs and serves as an animal model for human Lassa fever. An attenuated Pichinde virus variant (P2) and a virulent variant (P18) are being used to delineate pathogenic mechanisms that culminate in shock. In guinea pigs, the infection has been shown to begin in peritoneal macrophages following intraperitoneal inoculation and then spreads to the spleen and other reticuloendothelial organs. We show here that infection of the murine monocytic cell line P388D1 with either Pichinde virus variant resulted in the induction of inflammatory cytokines and effectors, including interleukin-6 and tumor necrosis factor alpha. Since these genes are regulated in part by the cellular transcription factors NF-kappaB and RBP-Jkappa, we compared the activities of NF-kappaB and RBP-Jkappa in P388D1 cells following infection with Pichinde virus. The attenuated P2 virus inhibited NF-kappaB activation and caused a shift in the size of the RBP-Jkappa complex. The virulent P18 virus showed less inhibition of NF-kappaB and failed to alter the size of the RBP-Jkappa complex. Peritoneal cells from P2-infected guinea pigs showed induction of NF-kappaB RelA/p50 heterodimer and p50/p50 homodimer and manifested an increase in the size of RBP-Jkappa. By contrast, P18 induced large amounts of the NF-kappaB p50/p50 dimer but failed to induce RelA/p50 or to cause an increase in the RBP-Jkappa size. Taken together, these changes suggest that the attenuated viral strain induces an "activation" of macrophages, while the virulent form of the virus does not.
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