ArticleJournal of virology2002
Dissociation of genome dimerization from packaging functions and virion maturation of human immunodeficiency virus type 1.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Human Retrovirus Genomic RNA Packaging.Viruses · 2022Review
- A novel role for gag as a cis-acting element regulating RNA structure, dimerization and packaging in HIV-1 lentiviral vectors.Nucleic acids research · 2022Article
- Development of a Novel Competitive qRT-PCR Assay to Measure Relative Lentiviral Packaging Efficiency.Molecular therapy. Methods & clinical development · 2020Article
- Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Conserved determinants of lentiviral genome dimerization.Retrovirology · 2015Article
- Mutational interference mapping experiment (MIME) for studying RNA structure and function.Nature methods · 2015Article
- Opening of the TAR hairpin in the HIV-1 genome causes aberrant RNA dimerization and packaging.Retrovirology · 2012Article
- Identification of a minimal region of the HIV-1 5'-leader required for RNA dimerization, NC binding, and packaging.Journal of molecular biology · 2012Article
- The relationship between HIV-1 genome RNA dimerization, virion maturation and infectivity.Nucleic acids research · 2011Article
- Structural dynamics of retroviral genome and the packaging.Frontiers in microbiology · 2011Article
- Secondary structure of the mature ex virio Moloney murine leukemia virus genomic RNA dimerization domain.Journal of virology · 2010Article
- High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states.PLoS biology · 2008Article
- Characterization of a natural heterodimer between MLV genomic RNA and the SD' retroelement generated by alternative splicing.RNA (New York, N.Y.) · 2007Article
- Minimal region sufficient for genome dimerization in the human immunodeficiency virus type 1 virion and its potential roles in the early stages of viral replication.Journal of virology · 2007Article
- Impaired RNA incorporation and dimerization in live attenuated leader-variants of SIVmac239.Retrovirology · 2006Article
- Analysis of the contribution of reverse transcriptase and integrase proteins to retroviral RNA dimer conformation.Journal of virology · 2005Article
- A riboswitch regulates RNA dimerization and packaging in human immunodeficiency virus type 1 virions.Journal of virology · 2004Article
- Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably?Retrovirology · 2004Review
- Possible role of dimerization in human immunodeficiency virus type 1 genome RNA packaging.Journal of virology · 2003Article
- Sequences downstream of the 5' splice donor site are required for both packaging and dimerization of human immunodeficiency virus type 1 RNA.Journal of virology · 2003Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dimer initiation site/dimer linkage sequence (DIS/DLS) region of the human immunodeficiency virus type 1 (HIV-1) RNA genome is thought to play important roles at various stages of the virus life cycle. Recently we showed that the DIS/DLS region affects RNA-RNA interaction in intact virus particles, by demonstrating that duplication of the region in viral RNA caused the production of virus particles containing partially monomeric RNAs. We have extended this finding and succeeded for the first time in creating mutant particles which contain only monomeric RNAs without modifying any viral proteins. In terms of RNA encapsidation ability, virion density, and protein processing, the mutant particles were comparable to wild-type particles. The level of production of viral DNA by the mutant virus construct in infected cells was also comparable to that of the constructs that produced exclusively dimeric RNA, indicating that monomeric viral RNA could be the template for strand transfer. These results indicated that the RNA dimerization of HIV-1 could be separated from viral RNA packaging and was not absolutely required for RNA packaging, virion maturation, and reverse transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.