ArticleThe Journal of physiology2002
Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of weightlessness on the cardiovascular system: a systematic review and meta-analysis.Frontiers in physiology · 2024Pooled it
- Transcutaneous electrical acupuncture stimulation as a countermeasure against cardiovascular deconditioning during 4 days of head-down bed rest in humans.Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2015Trial
- Effect of rowing ergometry and oral volume loading on cardiovascular structure and function during bed rest.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Trial
- Glycerol-induced fluid shifts attenuate the vestibulosympathetic reflex in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Trial
- Supine cycling plus volume loading prevent cardiovascular deconditioning during bed rest.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Trial
- Cerebral autoregulation is compromised during simulated fluctuations in gravitational stress.European journal of applied physiology · 2004Trial
- Analysis of raw microneurographic recordings based on wavelet de-noising technique and classification algorithm: wavelet analysis in microneurography.IEEE transactions on bio-medical engineering · 2003Trial
- Dose-dependent effects of graded altered gravity during hypovolaemia on central haemodynamics and cardiovascular autonomic regulation.Experimental physiology · 2026Article
- Three-week dry immersion results in a more severe impairment of cardiac baroreflex than head-down bed rest of the same duration.European journal of applied physiology · 2026Article
- Effects of different postures on the hemodynamics and cardiovascular autonomic control responses to exercise in postural orthostatic tachycardia syndrome.European journal of applied physiology · 2025Article
- Exercise training improves circulatory dynamics in adolescents with postural orthostatic tachycardia syndrome.Frontiers in pediatrics · 2025Article
- Lower body negative pressure identifies altered central vein characteristics without accompanying changes to baroreflexes in astronauts within hours of landing.Scientific reports · 2024Article
- Effects of aging and endurance exercise training on cardiorespiratory fitness and cardiac structure and function in healthy midlife and older women.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Response of cardiac pulse parameters in humans at various inclinations via 360° rotating platform for simulated microgravity perspective.NPJ microgravity · 2023Article
- Pathophysiological mechanism of acute bone loss after fracture.Journal of advanced research · 2023Review
- Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest.Frontiers in cardiovascular medicine · 2023Article
- Differential contributions of cardiac, coronary and pulmonary artery vagal mechanoreceptors to reflex control of the circulation.The Journal of physiology · 2022Review
- Cardiovascular autonomic nervous system responses and orthostatic intolerance in astronauts and their relevance in daily medicine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Implementation of exercise countermeasures during spaceflight and microgravity analogue studies: Developing countermeasure protocols for bedrest in older adults (BROA).Frontiers in physiology · 2022Review
6 more citing papers are in PubMed but not listed here.
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21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthostatic intolerance is common when astronauts return to Earth: after brief spaceflight, up to two-thirds are unable to remain standing for 10 min. Previous research suggests that susceptible individuals are unable to increase their systemic vascular resistance and plasma noradrenaline concentrations above pre-flight upright levels. In this study, we tested the hypothesis that adaptation to the microgravity of space impairs sympathetic neural responses to upright posture on Earth. We studied six astronauts approximately 72 and 23 days before and on landing day after the 16 day Neurolab space shuttle mission. We measured heart rate, arterial pressure and cardiac output, and calculated stroke volume and total peripheral resistance, during supine rest and 10 min of 60 deg upright tilt. Muscle sympathetic nerve activity was recorded in five subjects, as a direct measure of sympathetic nervous system responses. As in previous studies, mean (+/- S.E.M.) stroke volume was lower (46 +/- 5 vs. 76 +/- 3 ml, P = 0.017) and heart rate was higher (93 +/- 1 vs. 74 +/- 4 beats min(-1), P = 0.002) during tilt after spaceflight than before spaceflight. Total peripheral resistance during tilt post flight was higher in some, but not all astronauts (1674 +/- 256 vs. 1372 +/- 62 dynes s cm(-5), P = 0.32). No crew member exhibited orthostatic hypotension or presyncopal symptoms during the 10 min of postflight tilting. Muscle sympathetic nerve activity was higher post flight in all subjects, in supine (27 +/- 4 vs. 17 +/- 2 bursts min(-1), P = 0.04) and tilted (46 +/- 4 vs. 38 +/- 3 bursts min(-1), P = 0.01) positions. A strong (r(2) = 0.91-1.00) linear correlation between left ventricular stroke volume and muscle sympathetic nerve activity suggested that sympathetic responses were appropriate for the haemodynamic challenge of upright tilt and were unaffected by spaceflight. We conclude that after 16 days of spaceflight, muscle sympathetic nerve responses to upright tilt are normal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.