ArticleThe Journal of physiology2002
Influence of microgravity on astronauts' sympathetic and vagal responses to Valsalva's manoeuvre.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 95 citations in OpenAlex.
- Glycerol-induced fluid shifts attenuate the vestibulosympathetic reflex in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Trial
- Analysis of raw microneurographic recordings based on wavelet de-noising technique and classification algorithm: wavelet analysis in microneurography.IEEE transactions on bio-medical engineering · 2003Trial
- Three-week dry immersion results in a more severe impairment of cardiac baroreflex than head-down bed rest of the same duration.European journal of applied physiology · 2026Article
- Review of microgravity's impact on cardiovascular and nervous systems in space exploration.NPJ microgravity · 2025Review
- Mechanical loading on osteocytes regulates thermogenesis homeostasis of brown adipose tissue by influencing osteocyte-derived exosomes.Journal of orthopaedic translation · 2024Article
- Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest.Frontiers in cardiovascular medicine · 2023Article
- Cardiovascular autonomic nervous system responses and orthostatic intolerance in astronauts and their relevance in daily medicine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Implementation of exercise countermeasures during spaceflight and microgravity analogue studies: Developing countermeasure protocols for bedrest in older adults (BROA).Frontiers in physiology · 2022Review
- Impairment of synaptic plasticity and novel object recognition in the hypergravity-exposed rats.Scientific reports · 2020Article
- Vagal and Sympathetic Function in Neuropathic Postural Tachycardia Syndrome.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Altered baroreflex sensitivity in young women with a family history of hypertension.Journal of neurophysiology · 2019Article
- Effects of Prolonged Head-Down Bed Rest on Cardiac and Vascular Baroreceptor Modulation and Orthostatic Tolerance in Healthy Individuals.Frontiers in physiology · 2019Article
- Long-duration bed rest modifies sympathetic neural recruitment strategies in male and female participants.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Respiratory modulation of human autonomic function: long-term neuroplasticity in space.The Journal of physiology · 2016Article
- Respiratory modulation of human autonomic function on Earth.The Journal of physiology · 2016Article
- Protection against neurodegenerative disease on Earth and in space.NPJ microgravity · 2016Article
- The function of the autonomic nervous system during spaceflight.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2015Review
- Fluid shifts, vasodilatation and ambulatory blood pressure reduction during long duration spaceflight.The Journal of physiology · 2015Article
- Article
- Microgravity-induced fluid shift and ophthalmic changes.Life (Basel, Switzerland) · 2014Review
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23 authors at 12 institutions in 4 countries.
Funding
Abstract
When astronauts return to Earth and stand, their heart rates may speed inordinately, their blood pressures may fall, and some may experience frank syncope. We studied brief autonomic and haemodynamic transients provoked by graded Valsalva manoeuvres in astronauts on Earth and in space, and tested the hypothesis that exposure to microgravity impairs sympathetic as well as vagal baroreflex responses. We recorded the electrocardiogram, finger photoplethysmographic arterial pressure, respiration and peroneal nerve muscle sympathetic activity in four healthy male astronauts (aged 38-44 years) before, during and after the 16 day Neurolab space shuttle mission. Astronauts performed two 15 s Valsalva manoeuvres at each pressure, 15 and 30 mmHg, in random order. Although no astronaut experienced presyncope after the mission, microgravity provoked major changes. For example, the average systolic pressure reduction during 30 mmHg straining was 27 mmHg pre-flight and 49 mmHg in flight. Increases in muscle sympathetic nerve activity during straining were also much greater in space than on Earth. For example, mean normalized sympathetic activity increased 445% during 30 mmHg straining on earth and 792% in space. However, sympathetic baroreflex gain, taken as the integrated sympathetic response divided by the maximum diastolic pressure reduction during straining, was the same in space and on Earth. In contrast, vagal baroreflex gain, particularly during arterial pressure reductions, was diminished in space. This and earlier research suggest that exposure of healthy humans to microgravity augments arterial pressure and sympathetic responses to Valsalva straining and differentially reduces vagal, but not sympathetic baroreflex gain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.