ArticleThe Journal of physiology2002
Regulation of pacemaker frequency in the murine gastric antrum.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Differential responses to prostaglandins in the circular and longitudinal muscle layers of the murine ileum.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches.Frontiers in physiology · 2020Article
- The Role of Prostaglandins in Disrupted Gastric Motor Activity Associated With Type 2 Diabetes.Diabetes · 2019Article
- AqF026 is a pharmacologic agonist of the water channel aquaporin-1.Journal of the American Society of Nephrology : JASN · 2013Article
- On the origin of rhythmic contractile activity of the esophagus in early achalasia, a clinical case study.Frontiers in neuroscience · 2013Article
- Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor.Laboratory animal research · 2011Article
- Prostaglandin regulation of gastric slow waves and peristalsis.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- ATP induces guinea pig gallbladder smooth muscle excitability via the P2Y4 receptor and COX-1 activity.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Kit mutants and gastrointestinal physiology.The Journal of physiology · 2007Review
- Pacemaker currents modulated by C-type natriuretic peptide in interstitial cells of cajal from murine small intestine.Journal of physiology and biochemistry · 2006Article
- Interstitial cells of Cajal mediate mechanosensitive responses in the stomach.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Propagation of pacemaker activity in the guinea-pig antrum.The Journal of physiology · 2004Article
- Effects of gastric pacing on gastric emptying and plasma motilin.World journal of gastroenterology · 2004Article
- Pacing of interstitial cells of Cajal in the murine gastric antrum: neurally mediated and direct stimulation.The Journal of physiology · 2003Article
- Diagnosis and treatment of neuromuscular disorders of the stomach.Current gastroenterology reports · 2003Review
- Interstitial cells: involvement in rhythmicity and neural control of gut smooth muscle.The Journal of physiology · 2003Review
- Propagation of slow waves requires IP3 receptors and mitochondrial Ca2+ uptake in canine colonic muscles.The Journal of physiology · 2003Article
- Muscarinic regulation of pacemaker frequency in murine gastric interstitial cells of Cajal.The Journal of physiology · 2003Article
- Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine.British journal of pharmacology · 2002Article
- Characterization of the A-type potassium current in murine gastric antrum.The Journal of physiology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
PGE(2) has been linked to the production of gastric arrhythmias such as tachygastria. The interstitial cells of Cajal (ICC) generate electrical rhythmicity in gastrointestinal muscles, and may therefore be a target for PGE(2) in gastric muscles. We cultured ICC from the murine gastric antrum, verified that cells were Kit immunoreactive, and measured spontaneous slow waves. These events were caused by spontaneous inward (pacemaker) currents that were not blocked by nifedipine. Forskolin and 8-bromoadenosine 3':5'-cyclic monophosphate (8-Br-cAMP) reduced the frequency of pacemaker currents in ICC and of slow waves in intact antral muscles. The effects of forskolin and 8-Br-cAMP were not blocked by inhibitors of protein kinase A, suggesting that cAMP has direct effects on pacemaker activity. PGE(2) mimicked the effects of forskolin and 8-Br-cAMP on ICC, but increased slow-wave frequency in intact muscles. Therefore, the chronotropic effects of specific prostaglandin EP receptor agonists were examined. Butaprost and ONO-AE1-329, EP(2) and EP(4) receptor agonists, mimicked the effects of forskolin and 8-Br-cAMP on ICC and intact muscles. Sulprostone (EP(3)>EP(1) agonist), GR63799, and ONO-AE-248 (EP(3) agonists) enhanced the frequencies of pacemaker currents in ICC and slow waves in intact muscles. The effects of sulprostone were not blocked by SC-19220, an EP(1) receptor antagonist. These observations suggest that the positive chronotropic effects of PGE(2) in intact muscles are mediated by EP(3) receptor stimulation. The effects of PGE(2) in intact muscles may be dependent upon the relative expression of EP receptors and/or proximity of receptors to sources of PGE(2).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.