Evidence map›Paper›PMID 11773127›Full record

ArticleJournal of clinical microbiology2002

Accurate, noninvasive detection of Helicobacter pylori DNA from stool samples: potential usefulness for monitoring treatment.

Anthony P Shuber, Jennifer J Ascaño, Kevin A Boynton, Anastasia Mitchell, Henry F Frierson, Wa'el El-Rifai, Steven M Powell

Abstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Non-invasive diagnostic tests for Helicobacter pylori infection.The Cochrane database of systematic reviews · 2018
    Pooled it
  2. Article
  3. Article
  4. Noninvasive molecular analysis ofWorld journal of gastroenterology · 2017
    Review
  5. Intrafamilial Genotyping of Helicobacter pylori from Faecal DNA.Gastroenterology research and practice · 2011
    Article
  6. Role of NF2 haploinsufficiency in NF2-associated polyneuropathy.Brain pathology (Zurich, Switzerland) · 2007
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anthony P ShuberApplied Research Group, Exact Sciences Corporation, Maynard, Massachusetts 01754, USA.
Jennifer J Ascaño
Kevin A Boynton
Anastasia Mitchell
Henry F Frierson
Wa'el El-Rifai
Steven M Powell

Funding

GENETIC ALTERATIONS IN GASTRIC CARCINOMASR01CA067900 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI POWELL, STEVEN M · 2000 to 2004
$1.3M
GENETIC ALTERATIONS IN GASTRIC CARCINOMASR29CA067900 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI POWELL, STEVEN M · 1995 to 1999
–
NCI NIH HHS CA67900-06NCI NIH HHS R01 CA067900NCI NIH HHS R29 CA067900
6 · The paper itself

Abstract

A novel DNA assay demonstrating sensitive and accurate detection of Helicobacter pylori from stool samples is reported. Moreover, in three individuals tested for therapeutic response, the assay showed the disappearance of H. pylori DNA during treatment. Thus, this noninvasive molecular biology-based assay has the potential to be a powerful diagnostic tool given its ability to specifically identify H. pylori DNA.

Indexed as

DNA, BacterialFecesHelicobacter InfectionsHelicobacter pyloriHumansPolymerase Chain ReactionSensitivity and SpecificityDNA, Bacterial

Identifiers

PMID11773127
PMCPMC120120

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.