ArticleGut2002
Helicobacter pylori stimulates pepsinogen secretion from isolated human peptic cells.
Article in Gut, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.Gastroenterology · 2021Guideline
- Gastric cancer screening using the serum pepsinogen test method.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2006Pooled it
- The potential value of serum pepsinogen and gastrin-17 for the diagnosis of chronic atrophic gastritis at different stages of severity: a clinical diagnostic study.BMC gastroenterology · 2025Article
- Article
- Useful Serum Pepsinogen Levels for Detecting Ongoing Helicobacter pylori Infection in Asymptomatic Subjects: A Cross-Sectional Study Based onDigestive diseases and sciences · 2022Article
- Risk Score Using Demographic and Clinical Risk Factors Predicts Gastric Intestinal Metaplasia Risk in a U.S. Population.Digestive diseases and sciences · 2022Article
- Clinical Value of Combined Detection of Serum sTim-3 and Pepsinogen for Gastric Cancer Diagnosis.Cancer management and research · 2021Article
- Article
- Clinical correlation between serum pepsinogen level and gastric atrophy in gastric neoplasm.The Korean journal of internal medicine · 2020Article
- Pepsinogen Serology and Gastritis OLGA Staging in Mucosal Atrophy Assessment: A Cross-Sectional Study Involving East China Endoscopy Population.Gastroenterology research and practice · 2020Article
- Immunopathological and Modulatory Effects ofOpen access Macedonian journal of medical sciences · 2018Article
- Three-dimensional combined biomarkers assay could improve diagnostic accuracy for gastric cancer.Scientific reports · 2017Article
- The serum pepsinogen levels for risk assessment of gastric neoplasms: New proposal from a case-control study in Korea.Medicine · 2017Article
- Gastric mucosal status in populations with a low prevalence of Helicobacter pylori in Indonesia.PloS one · 2017Article
- The new modified ABCD method for gastric neoplasm screening.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Article
- Helicobacter pylori Infection Status Correlates with Serum Parameter Levels Responding to Multi-organ Functions.Digestive diseases and sciences · 2015Article
- The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China.BMC gastroenterology · 2014Article
- Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease.BMC clinical pathology · 2013Article
- Low Levels of Pepsinogen I and Pepsinogen I/II Ratio are Valuable Serologic Markers for Predicting Extensive Gastric Corpus Atrophy in Patients Undergoing Endoscopic Mucosectomy.Gut and liver · 2010Article
- Clinical relevance of cagPAI intactness in Helicobacter pylori isolates from Vietnam.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferent acid and peptic related gastroduodenal diseases are associated with both increased gastric secretion and Helicobacter pylori infection. Patients with H pylori associated gastritis or duodenal ulcer have increased serum pepsinogen levels which decrease after eradication. The mechanisms of H pylori induced gastric mucosal damage are not completely understood.
aimTo determine the effects of H pylori on pepsinogen secretion from isolated human peptic cells.
methodsDispersed human peptic cells were prepared from endoscopically obtained biopsy specimens after collagenase digestion, mechanical disruption, and density gradient centrifugation. H pylori was obtained from gastric biopsies (antrum and body), and cultured in non-selective and selective media. Isolates of H pylori were used at different concentrations (1 - 20 x 10(6) colony forming units (cfu)).
resultsH pylori (10(6) - 2 x 10(7) cfu) increased basal pepsinogen secretion in a concentration dependent manner. This stimulus was not observed with Escherichia coli. The increased secretion was in addition to that observed with 0.1 mM histamine and 0.1 mM dibutyryl-cyclic adenosine monophosphate. However, H pylori did not affect either carbamylcholine (0.1-10 microM) or cholecystokinin (1 microM) stimulated pepsinogen secretion. Addition of the nitric oxide synthase inhibitor N(w)-monomethyl-L-arginine (1 mM) inhibited H pylori induced cGMP generation and pepsinogen secretion, which were also reduced in the absence of extracellular calcium. H pylori induced pepsinogen secretion was not affected by the absence/presence of the cagA gene.
conclusionsH pylori increases pepsinogen secretion from human peptic cells through a calcium and nitric oxide mediated intracellular pathway. This effect is independent of the H pylori virulent cagA gene, and may be a mechanism of H pylori induced gastric mucosal damage.
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