ArticleBrain pathology (Zurich, Switzerland)2002
Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas.
Article in Brain pathology (Zurich, Switzerland), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 127 citations in OpenAlex.
- Molecular and clinical heterogeneity within MYC-family amplified medulloblastoma is associated with survival outcomes: A multicenter cohort study.Neuro-oncology · 2025Article
- Large cell anaplastic medulloblastoma metastatic to the scalp: tumor and derived stem-like cells features.BMC cancer · 2014Article
- G-quadruplexes as potential therapeutic targets for embryonal tumors.Molecules (Basel, Switzerland) · 2013Review
- Medulloblastoma: recurrence and metastasis.CNS oncology · 2013Review
- Myc proteins in brain tumor development and maintenance.Upsala journal of medical sciences · 2012Article
- Matching mice to malignancy: molecular subgroups and models of medulloblastoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Review
- Impact of molecular biology studies on the understanding of brain tumors in childhood.Current oncology reports · 2012Article
- Aggressive large cell medulloblastoma extending to the extracranial region in brain-dead state.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2011Article
- Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma.Neuro-oncology · 2011Article
- Chromosome 17 alterations identify good-risk and poor-risk tumors independently of clinical factors in medulloblastoma.Neuro-oncology · 2011Article
- Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma.Journal of neuro-oncology · 2011Article
- Molecular diagnostics in embryonal brain tumors.Brain pathology (Zurich, Switzerland) · 2011Review
- Molecular diagnostics of CNS embryonal tumors.Acta neuropathologica · 2010Review
- Article
- Pleiotropic role for MYCN in medulloblastoma.Genes & development · 2010Article
- High-risk medulloblastoma: does c-myc amplification overrule histopathology?Pediatric blood & cancer · 2010Article
- Medulloblastomas: a correlative study of MIB-1 proliferation index along with expression of c-Myc, ERBB2, and anti-apoptotic proteins along with histological typing and clinical outcome.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009Article
- N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.Genes & development · 2009Article
- Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective.Neuro-oncology · 2008Review
- Large cell medulloblastoma with myogenic and melanotic differentiation: a case report with molecular analysis.Journal of neuro-oncology · 2008Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We correlate chromosomal changes in medulloblastomas with histologic subtype, reporting the analysis of 33 medulloblastoma specimens by comparative genomic hybridization, and a subset by fluorescence in situ hybridization. Of the 33 tumors, 5 were desmoplastic/nodular, 10 were histologically classic, and 18 were large cell/anaplastic. Chromosomal gains and losses were more common in anaplastic medulloblastomas than in non-anaplastic ones. We identified 4 medulloblastomas with c-myc amplification and 5 medulloblastomas with N-myc amplification; all 9 were of the large cell/anaplastic subtype. Additional regions with high level gains included 2q14-22, 3p23, 5p14-pter, 8q24, 9p22-23, 10p12-pter, 12q24, 12p11-12, 17p11-12, and Xp11. The majority of these high level gains occurred in anaplastic cases. We also found loss of chromosome 17p in 7 large cell/anaplastic cases but no nonanaplastic medulloblastomas. Finally, we detected a significantly increased overall number of chromosomal alterations in large cell/anaplastic medulloblastomas (6.8/case) compared to non-anaplastic ones (3.3/case). These findings support an association between myc oncogene amplification, 17p loss, and large cell/anaplastic histology.
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