ReviewJournal of bioenergetics and biomembranes2000
The local control of cytosolic Ca2+ as a propagator of CNS communication--integration of mitochondrial transport mechanisms and cellular responses.
Review in Journal of bioenergetics and biomembranes, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Synaptopathy Mechanisms in ALS Caused by C9orf72 Repeat Expansion.Frontiers in cellular neuroscience · 2021Article
- Mitochondria and Synaptic Plasticity in the Mature and Aging Nervous System.Current neuropharmacology · 2017Review
- Role of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks.NMR in biomedicine · 2015Article
- Mitochondrial calcium uptake capacity modulates neocortical excitability.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Mitochondrial functional state impacts spontaneous neocortical activity and resting state FMRI.PloS one · 2013Article
- Calcineurin regulates myocardial function during acute endotoxemia.American journal of respiratory and critical care medicine · 2006Article
- Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.Neuromolecular medicine · 2006Article
- Mitochondrial regulation of neuronal plasticity.Neurochemical researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ca2+ signals propagate in wave form along individual cells of the central nervous system (CNS) and through networks of connected cells of neuronal and multiple glial cell types. In order for wave fronts to convey information, signaling mechanisms are required that allow waves to propagate reproducibly and without decrement in signal strength over long distances. CNS Ca2+ waves are under specific integrated local control, made possible by interactions at local subcellular microdomains between endoplasmic reticulum and mitochondria. Active mitochondria located near the mouth of inositol trisphosphate receptor (InsP3R) channel clusters in glia take up Ca2+, which may prevent a buildup of Ca2+ around the InsP3R channel, thereby decreasing the rate of Ca2+-induced receptor inactivation, and prolonging channel open time. Mitochondria may amplify InsP3-dependent Ca2+ signals by a transient permeability transition in response to Ca2+ uptake into the mitochondrion. Other evidence suggests privileged access into mitochondria for Ca2+ entering neurons by glutamatergic receptor channels. This enables specific signal modulation as the Ca2+ wave is propagated into neurons, such that mitochondria located close to glutamate channels can prolong the neuronal cytosolic response time by successive uptake and release of Ca2+. Disruption of mitochondrial function deregulates the ability of CNS-derived cells to undergo normal Ca2+ signaling and wave propagation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.