ReviewJournal of bioenergetics and biomembranes2000
Mitochondrial calcium signaling driven by the IP3 receptor.
Review in Journal of bioenergetics and biomembranes, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 71 citations in OpenAlex.
- Creating a New Cancer Therapeutic Agent by Targeting the Interaction between Bcl-2 and IPCold Spring Harbor perspectives in biology · 2019Review
- Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells.American journal of physiology. Cell physiology · 2017Article
- Glial cell regulation of rhythmic behavior.Methods in enzymology · 2015Review
- Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment.Biochimica et biophysica acta · 2014Review
- ER-mitochondrial calcium flow underlies vulnerability of mechanosensory hair cells to damage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Bcl-xL in neuroprotection and plasticity.Frontiers in physiology · 2014Review
- Stroke neuroprotection: targeting mitochondria.Brain sciences · 2013Article
- Expression of a truncated form of the endoplasmic reticulum chaperone protein, σ1 receptor, promotes mitochondrial energy depletion and apoptosis.The Journal of biological chemistry · 2012Article
- Immunocytochemical analysis of P2X2 in rat circumvallate taste buds.BMC neuroscience · 2012Article
- Article
- Integration of ER stress, oxidative stress and the inflammatory response in health and disease.International journal of clinical and experimental medicine · 2010Article
- Structural and functional link between the mitochondrial network and the endoplasmic reticulum.The international journal of biochemistry & cell biology · 2009Review
- Mitochondria in cardiomyocyte Ca2+ signaling.The international journal of biochemistry & cell biology · 2009Review
- Sodium-calcium exchangers contribute to the regulation of cytosolic calcium levels in mouse taste cells.The Journal of physiology · 2009Article
- Mitochondrial calcium buffering contributes to the maintenance of Basal calcium levels in mouse taste cells.Journal of neurophysiology · 2008Article
- Article
- Purinergic receptor-stimulated IP3-mediated Ca2+ release enhances neuroprotection by increasing astrocyte mitochondrial metabolism during aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis.Oncogene · 2004Article
- Nitric oxide inhibits capacitative Ca2+ entry by suppression of mitochondrial Ca2+ handling.British journal of pharmacology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Many agonists bring about their effects on cellular functions through a rise in cytosolic [Ca2+] ([Ca2+]c) mediated by the second messenger inositol 1,4,5-trisphosphate (IP3). Imaging studies of single cells have demonstrated that [Ca2+]c signals display cell specific spatiotemporal organization that is established by coordinated activation of IP3 receptor Ca2+ channels. Evidence emerges that cytosolic calcium signals elicited by activation of the IP3 receptors are efficiently transmitted to the mitochondria. An important function of mitochondrial calcium signals is to activate the Ca2+-sensitive mitochondrial dehydrogenases, and thereby to meet demands for increased energy in stimulated cells. Activation of the permeability transition pore (PTP) by mitochondrial calcium signals may also be involved in the control of cell death. Furthermore, mitochondrial Ca2+ transport appears to modulate the spatiotemporal organization of [Ca2+]c responses evoked by IP3 and so mitochondria may be important in cytosolic calcium signaling as well. This paper summarizes recent research to elucidate the mechanisms and significance of IP3-dependent mitochondrial calcium signaling.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.