ArticleDigestive diseases and sciences2001
Superoxide anion and nitric oxide in high-grade esophagitis induced by acid and pepsin in rabbits.
Article in Digestive diseases and sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Acid challenge to the esophageal mucosa: effects on local nitric oxide formation and its relation to epithelial functions.Digestive diseases and sciences · 2005Trial
- Flavonoids from whole Plant ofPharmacognosy magazine · 2017Article
- Gaseous mediators nitric oxide and hydrogen sulfide in the mechanism of gastrointestinal integrity, protection and ulcer healing.Molecules (Basel, Switzerland) · 2015Review
- Ischemic heart disease, factor predisposing to Barrett's adenocarcinoma: A case control study.World journal of gastrointestinal pharmacology and therapeutics · 2014Article
- The integrity of the esophageal mucosa. Balance between offensive and defensive mechanisms.Best practice & research. Clinical gastroenterology · 2010Review
- Reactive oxygen species and chemokines: are they elevated in the esophageal mucosa of children with gastroesophageal reflux disease?World journal of gastroenterology · 2008Article
- Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett's esophagus.World journal of gastroenterology · 2005Article
- Free radicals and antioxidant systems in reflux esophagitis and Barrett's esophagus.World journal of gastroenterology · 2005Article
- Functional oesophageal epithelial defense against acid.Inflammopharmacology · 2005Review
- Selective COX-2 inhibition is associated with decreased mucosal damage induced by acid and pepsin in rabbit esophagitis.Inflammation · 2003Article
- Analysis of mucosal stress response in acid-induced esophagitis in opossum.Digestive diseases and sciences · 2002Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been proposed that free radicals are involved in the pathogenesis of esophageal mucosal damage induced by acid and pepsin. Recent data have suggested that nitric oxide (NO) is involved in the mucosal defense of the esophagus and that superoxide anion plays a minor role in low-grade esophagitis. To study the role and potential interaction of NO and superoxide anion in an experimental model of high-grade esophagitis, acidified pepsin was perfused (45 min/12 hr) for five days in rabbits with different agents to modulate the generation of these radicals. Measurements included both macroscopic and microscopic mucosal damage, superoxide anion generation, NO synthase mucosal activity, and peroxynitrite formation. High-grade esophagitis was associated with mucosal superoxide anion generation. Treatment with exogenous superoxide dismutase completely prevented mucosal damage. The perfusion of acidified pepsin in the lumen of the esophagus was initially associated with increased NO synthase mucosal activity but decreased with the progression of damage. Generation of peroxynitrites was present in those cases with severe damage. Treatment with NO-modifying agents did not induce consistent modification of mucosal damage. It is concluded that superoxide anion is involved in the induction of high-grade esophagitis and that it interacts with nitric oxide to generate peroxynitrite radicals in this model. Superoxide dismutase but not NO-donor-modifying agents might have a therapeutic role in preventing severe esophageal mucosal damage induced by acid and pepsin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.