ArticleDigestive diseases and sciences2001
Mechanisms and roles of neutrophil infiltration in stress-induced gastric injury in rats.
Article in Digestive diseases and sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 69 citations in OpenAlex.
- Ameliorative Effect of Green Bimetallic Zinc Oxide-Magnesium Oxide Nanoparticles Against Gastric Ulcer in Rats via Modulation of Oxidative Stress, Inflammatory Cascades, Nrf2/NF-κB Signaling, Angiogenic VEGF Expression.Biological trace element research · 2026Article
- Characterization of gastric ulcer influenced by hot-humid environment and high-sugar and high-fat diet provides a further insight into its underlying mechanism.Scientific reports · 2025Article
- Individual and synergistic protective properties ofRSC advances · 2020Article
- Esomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways.Drug design, development and therapy · 2019Article
- Silver oxide nanoparticles alleviate indomethacin-induced gastric injury: a novel antiulcer agent.Inflammopharmacology · 2018Article
- Effect of water-immersion restraint stress on tryptophan catabolism through the kynurenine pathway in rat tissues.The journal of physiological sciences : JPS · 2017Article
- Anti-Ulcerogenic Properties of Lycium chinense Mill Extracts against Ethanol-Induced Acute Gastric Lesion in Animal Models and Its Active Constituents.Molecules (Basel, Switzerland) · 2015Article
- Clinical application of kampo medicine (rikkunshito) for common and/or intractable symptoms of the gastrointestinal tract.Frontiers in pharmacology · 2015Article
- The gastroprotective effect of menthol: involvement of anti-apoptotic, antioxidant and anti-inflammatory activities.PloS one · 2014Article
- Protective Effect of Repeatedly Preadministered Brazilian Propolis Ethanol Extract against Stress-Induced Gastric Mucosal Lesions in Rats.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats.Journal of physiology and biochemistry · 2013Article
- Kampo medicines for gastrointestinal tract disorders: a review of basic science and clinical evidence and their future application.Journal of gastroenterology · 2013Review
- Protective effect of 3,4-methylenedioxyphenol (sesamol) on stress-related mucosal disease in rats.BioMed research international · 2013Article
- Gastritis induced by Helicobacter pylori infection in experimental rats.Digestive diseases and sciences · 2010Article
- Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats.Journal of gastroenterology · 2009Article
- Effect of some natural products either alone or in combination on gastritis induced in experimental rats.Digestive diseases and sciences · 2008Article
- Anti-inflammatory effects of pravastatin on Helicobacter pylori-induced gastritis in mice.Digestive diseases and sciences · 2007Article
- Attenuation of gastric mucosal inflammation induced by aspirin through inhibition of selective type III phospshodiesterase in rats.Digestive diseases and sciences · 2007Article
- Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats.World journal of gastroenterology · 2006Article
- Effect of cilostazol, a selective type-III phosphodiesterase inhibitor, on water-immersion stress-induced gastric mucosal injury in rats.Journal of gastroenterology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Water-immersion and restraint stress is associated with an increase in neutrophil infiltration into the gastric mucosa, but the mechanism responsible for this infiltration is unclear. We investigated the involvement of intercellular adhesion molecule-1 (ICAM-1) and tumor necrosis factor-alpha (TNF-alpha) in neutrophil infiltration in stress-induced gastric injury in rats. Rats were administered neutralizing antibody against ICAM-1 or TNF-alpha and were subjected to induction of gastric injury by 6-hr water-immersion and restraint stress. To evaluate the relationship between gastric acid and neutrophil infiltration, some rats were given cimetidine before administration of stress. Neutralizing antibodies inhibited both the lesion formation and the increase in myeloperoxidase activity induced by stress. Expression of ICAM-1 on endothelial cells was increased by stress, accompanied by an increase of TNF-alpha-positive cells. Antibody against TNF-alpha inhibited this increase in ICAM-1 expression. Cimetidine almost completely inhibited gastric lesions, but did not affect myeloperoxidase activity. In conclusion, neutrophil infiltration in stress-induced gastric injury may be mediated by ICAM-1 and TNF-alpha, but not gastric acid, and may play crucial roles in the progression of gastric injury.
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