ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2001
Effects of exogenous recombinant interleukin-12 on immune responses and protection against Brucella abortus in a murine model.
Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates.BMC bioinformatics · 2013Pooled it
- Immune responses and safety after dart or booster vaccination of bison with Brucella abortus strain RB51.Clinical and vaccine immunology : CVI · 2012Trial
- Breed-specific innate immune responses to Brucella abortus strain RB51 and Bacillus Calmette-Guérin in cattle.Scientific reports · 2026Article
- Innate Immunity Trained in the Protective Response of Vaccine Candidates Against Intracellular Pathogens.Vaccines · 2026Article
- Comparison of bison and elk susceptibility to experimental challenge withFrontiers in veterinary science · 2024Article
- Characterization of the adaptive cellular and humoral immune responses to persistent colonization ofFrontiers in veterinary science · 2024Article
- Fecal and vaginal microbiota of vaccinated and non-vaccinated pregnant elk challenged withFrontiers in veterinary science · 2024Article
- Influence of species of negative control sera on results of a brucellosis fluorescence polarization assay.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
- Immune Responses and Efficacy ofFrontiers in veterinary science · 2021Article
- Article
- Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene expression in brucellosis.BMC molecular biology · 2018Article
- Article
- Vaccination of Elk (Cervus canadensis) with Brucella abortus Strain RB51 Overexpressing Superoxide Dismutase and Glycosyltransferase Genes Does Not Induce Adequate Protection against Experimental Brucella abortus Challenge.Frontiers in cellular and infection microbiology · 2016Article
- Immune responses of bison and efficacy after booster vaccination with Brucella abortus strain RB51.Clinical and vaccine immunology : CVI · 2015Article
- Efficacy of dart or booster vaccination with strain RB51 in protecting bison against experimental Brucella abortus challenge.Clinical and vaccine immunology : CVI · 2012Article
- Comparison of abortion and infection after experimental challenge of pregnant bison and cattle with Brucella abortus strain 2308.Clinical and vaccine immunology : CVI · 2011Article
- Immune responses and protection against experimental challenge after vaccination of bison with Brucella abortus strain RB51 or RB51 overexpressing superoxide dismutase and glycosyltransferase genes.Clinical and vaccine immunology : CVI · 2009Article
- Defensin susceptibility and colonization in the mouse model of AJ100, a polymyxin B-resistant, Brucella abortus RB51 isolate.Current microbiology · 2008Article
- Immune responses of elk to initial and booster vaccinations with Brucella abortus strain RB51 or 19.Clinical and vaccine immunology : CVI · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study determined if murine interleukin-12 (IL-12) would influence immunity in mice vaccinated with live or killed Brucella abortus strain RB51 (SRB51). Mice received live or gamma-irradiated SRB51 bacteria alone, or with IL-12 (0.5 or 1.0 microg, 2x or 3x), whereas other mice received saline or IL-12 alone. Post-vaccination antibody responses to live or killed SRB51 and clearance of live SRB51 from splenic tissue were not influenced by IL-12 treatments. Mice were challenged at 12 weeks with 4 x 10(4) cfu of B. abortus strain 2308 (S2308) and were euthanized 2 weeks later. The highest IL-12 treatment increased (P < 0.05) post-challenge antibody responses when co-administered with killed SRB51. Co-administration of 1.0 microg of IL-12 with live SRB51, but not killed SRB51, reduced (P < 0.05) S2308 colonization of splenic tissues. Our data suggest that although IL-12 may augment protective immunity induced by live SRB51, it does not influence protection induced by vaccination with killed SRB51.
Indexed as
Identifiers
11768128PMC1189683W2292086893What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.