ArticleJournal of endocrinological investigation2001
Thyroid ultrasonography as a tool for detecting thyroid autoimmune diseases and predicting thyroid dsfunction in apparently healthy subjects.
Article in Journal of endocrinological investigation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 153 citations in OpenAlex.
- Hyperhomocysteinemia in acute iatrogenic hypothyroidism: the relevance of thyroid autoimmunity.Journal of endocrinological investigation · 2018Trial
- A randomized-controlled, double-blind study of the impact of selenium supplementation on thyroid autoimmunity and inflammation with focus on the GPx1 genotypes.Journal of endocrinological investigation · 2015Trial
- Low-level laser in the treatment of patients with hypothyroidism induced by chronic autoimmune thyroiditis: a randomized, placebo-controlled clinical trial.Lasers in medical science · 2013Trial
- Thyroid function and ultrasound surveillance in childhood cancer survivors (CCS): a position paper of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED).Journal of endocrinological investigation · 2026Review
- Serum Negative Chronic Autoimmune Thyroiditis (SN-CAT): A Case Report of Three Siblings Without Familial History of Autoimmune Thyroid Diseases (ATDs).Clinical case reports · 2026Article
- Serum Cocaine- and Amphetamine-Regulated Transcript (CART) Levels in Graves' Disease: Associations with Metabolic Status, Autoimmunity, and Thyroid Ultrasound Heterogeneity.International journal of molecular sciences · 2026Article
- Analysis of risk factors for hypothyroidism in initially euthyroid patients with positive thyroid autoantibodies: a multicenter retrospective cohort study.Frontiers in endocrinology · 2026Article
- Prediction of Seronegative Hashimoto's thyroiditis using machine learning models based on ultrasound radiomics: a multicenter study.BMC immunology · 2025Article
- Autoimmunity, New Potential Biomarkers and the Thyroid Gland-The Perspective of Hashimoto's Thyroiditis and Its Treatment.International journal of molecular sciences · 2024Review
- Principles and features of ultrasound hypoechogenicity in diffuse thyroid pathology.Quantitative imaging in medicine and surgery · 2024Review
- Fifteen Years of Iodine Prophylaxis in Italy: Results of a Nationwide Surveillance (Period 2015-2019).The Journal of clinical endocrinology and metabolism · 2024Article
- AI-Assisted Ultrasound for the Early Diagnosis of Antibody-Negative Autoimmune Thyroiditis.Journal of multidisciplinary healthcare · 2023Review
- Article
- Review
- Association between High Normal TSH Levels and Obesity in Women with Anti-Thyroid Autoantibodies (ATAs).Journal of clinical medicine · 2022Article
- Dynamic follow-up of the effects of programmed death 1 inhibitor treatment on thyroid function and sonographic features in patients with hepatocellular carcinoma.Endocrine connections · 2022Article
- Higher SARS-CoV-2 viral loads correlated with smaller thyroid volumes on ultrasound among male COVID-19 survivors.Endocrine · 2021Article
- The relationship between ultrasound findings and thyroid function in children and adolescent autoimmune diffuse thyroid diseases.Scientific reports · 2021Article
- Risk of Benign and Malignant Thyroid Disorders in Subjects Treated for Paediatric/Adolescent Neoplasia: Role of Morphological and Functional Screening.Children (Basel, Switzerland) · 2021Article
- A new risk factor indicator for papillary thyroid cancer based on immune infiltration.Cell death & disease · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledIn order to establish its usefulness for the diagnosis and follow-up of thyroid autoimmune diseases, thyroid ultrasonography together with free T4 (FT4), free T3 (FT3), TSH, antibodies (Tg Ab) and thyroperoxidase antibodies (TPO Ab) were performed and re-evaluated during a 3-yr follow-up in 482 apparently healthy subjects, living in a borderline iodine-sufficient urban area. Thyroid dysfunction was found in 7 out of 12 (58.3%) subjects with circulating thyroid autoantibodies, who also had thyroid hypoechogenicity (2 had overt and 3 subclinical hypothyroidism at booking; 2 developed subclinical hypothyroidism during the follow-up), and in none of the 12 subjects with normal thyroid echostructure (chi2=7.26, p=0.007). Thyroid dysfunction was found in 4 out of 29 (13.7%) subjects with negative Tg and/or TPO Ab who also had thyroid hypoechogenicity (1 had Graves' disease at booking, 1 developed Graves' disease and 2 subclinical hypothyroidism during the follow-up), and in none of the 429 with normal thyroid echostructure (chi2=82.03, p<0.0001). Although positive TPO and/or Tg Ab were more frequent (24/482, 5%) in subjects with thyroid dysfunction (7/11) than in those who remained euthyroid during the study (17/471, chi2=69.66, p<0.0001), thyroid hypoechogenicity had a higher sensitivity than the positivity of thyroid autoantibody tests (100 vs 63.3%) for diagnosing or predicting thyroid dysfunction. IN
conclusion1) thyroid ultrasonography is a useful tool to detect thyroid autoimmune disease in apparently healthy subjects; 2) present and future thyroid dysfunction is more readily predicted by a hypoechogenic pattern at thyroid ultrasound than by the occurrence of serum thyroid autoantibodies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.