ArticleJournal of neuro-oncology2001
Invasiveness in vitro and biological markers in human primary glioblastomas.
Article in Journal of neuro-oncology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Phase II trial of intratumoral BCNU injection and radiotherapy on untreated adult malignant glioma.Journal of neuro-oncology · 2010Trial
- Golgi phosphoprotein 3 sensitizes the tumour suppression effect of gefitinib on gliomas.Cell proliferation · 2019Article
- MiR-145 reduces ADAM17 expression and inhibits in vitro migration and invasion of glioma cells.Oncology reports · 2013Article
- Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells.The Journal of biological chemistry · 2009Article
- A coculture assay to visualize and monitor interactions between migrating glioma cells and nerve fibers.Nature protocols · 2009Article
- Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness.Molecular cancer research : MCR · 2008Article
- Sensitization of cerebral tissue in nude mice with photodynamic therapy induces ADAM17/TACE and promotes glioma cell invasion.Cancer letters · 2008Article
- Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness.Cancer science · 2007Article
- Proliferation, migration, and invasion of human glioma cells exposed to fractionated radiotherapy in vitro.Neurosurgical review · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invasion of spheroids from 20 human primary glioblastomas into precultured fetal rat brain tissue in culture has been studied and quantified. Between 30 and 98 percent of the normal brain tissue was destroyed by invading glioma cells within 4 days. The degree of invasion did not correlate with patient survival. A slightly higher invasiveness and shorter survival was seen in tumors with EGF receptor overexpression, and the opposite pattern was found for tumors with a TP53 mutation. The degree of invasiveness in vitro was far higher than would be expected from the dynamics of clinically observed tumor spread. This suggests that mechanisms suppressing invasion may be operative in the normal brain; alternatively the differences may be due to a higher permissiveness of the fetal brain tissue for invasion in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.