ReviewBiomaterials2002
The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides.
Review in Biomaterials, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 127 citations in OpenAlex.
- Design and Characterization of Hybrid Multilayer Structures: Layer-by-Layer Growth of Polymer and Graphene Oxide Assemblies and Their Utility in Fuel Cell Applications.ACS applied energy materials · 2026Article
- Imaging-Assisted Antisense Oligonucleotide Delivery for Tumor-Targeted Gene Therapy.Chemical & biomedical imaging · 2024Review
- Alternative therapeutic strategies to treat antibiotic-resistant pathogens.Nature reviews. Microbiology · 2024Review
- Systematic Combination of Oligonucleotides and Synthetic Polymers for Advanced Therapeutic Applications.Macromolecular research · 2021Review
- Enhanced lysosome escape mediated by 1,2-dicarboxylic-cyclohexene anhydride-modified poly-l-lysine dendrimer as a gene delivery system.Asian journal of pharmaceutical sciences · 2020Article
- MicroRNAs in brain metastases: potential role as diagnostics and therapeutics.International journal of molecular sciences · 2014Review
- Canonical and non-canonical barriers facing antimiR cancer therapeutics.Current medicinal chemistry · 2013Review
- MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals.Molecular carcinogenesis · 2012Review
- Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy.International journal of nanomedicine · 2012Review
- Approaches to manipulating microRNAs in neurogenesis.Frontiers in neuroscience · 2012Article
- MicroRNAs Regulate Key Effector Pathways of Senescence.Journal of aging research · 2011Article
- Micro-RNA Expression and Function in Lymphomas.Advances in hematology · 2011Article
- Targeting microRNAs in cancer: rationale, strategies and challenges.Nature reviews. Drug discovery · 2010Review
- Novel graft copolymers enhance in vitro delivery of antisense oligonucleotides in the presence of serum.Journal of controlled release : official journal of the Controlled Release Society · 2009Article
- Noncovalent complexes between DNA and basic polypeptides or polyamines by MALDI-TOF.Journal of the American Society for Mass Spectrometry · 2007Article
- Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Tracking the pathway of calcium phosphate/DNA nanoparticles during cell transfection by incorporation of red-fluorescing tetramethylrhodamine isothiocyanate-bovine serum albumin into these nanoparticles.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2007Article
- A study of noncovalent complexes involving single-stranded DNA and polybasic compounds using nanospray mass spectrometry.Journal of the American Society for Mass Spectrometry · 2007Article
- Bioconjugation of oligonucleotides for treating liver fibrosis.Oligonucleotides · 2007Review
- Oligonucleotide structure influences the interactions between cationic polymers and oligonucleotides.BiomacromoleculesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developed over the past two decades, the antisense strategy has become a technology of recognised therapeutic potential, and many of the problems raised earlier in its application have been solved to varying extents. However, the adequate delivery of antisense oligodeoxynucleotides to individual cells remains an important and inordinately difficult challenge. Synthetic polymers appeared on this scene in the middle 1980s, and there is a surprisingly large variety used or proposed so far as agents for delivery of oligodeoxynucleotides. After discussing the principles of antisense strategy, certain aspects of the ingestion of macromolecules by cells, and the present situation of delivery procedures, this article analyses in detail the attempts to use synthetic polymers as carrier matrices and or cell membrane permeabilisation agents for delivery of antisense oligodeoxynucleotides. Structural aspects of various polymers, as well as the results, promises and limitations of their use are critically evaluated.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.