ReviewAdvances in parasitology2001
The malaria-infected red blood cell: structural and functional changes.
Review in Advances in parasitology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed.
- Article
- Russian Dolls of Heme Metabolism in Malaria-Infected Red Blood Cells: Nested Vulnerabilities and Therapeutic Opportunities.Pathogens (Basel, Switzerland) · 2026Review
- Targeting Infected Host Cell Heme Metabolism to Kill Malaria Parasites.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Contact Dynamics of CytoadheringACS infectious diseases · 2025Article
- Non-Invasive Malaria Detection in Sub-Saharan Africa Using a DNA-Based Sensor System.Sensors (Basel, Switzerland) · 2024Article
- Numerical investigation of heterogeneous soft particle pairs in inertial microfluidics.Soft matter · 2024Article
- Investigation of Soft Matter Nanomechanics by Atomic Force Microscopy and Optical Tweezers: A Comprehensive Review.Nanomaterials (Basel, Switzerland) · 2023Review
- Automated Recognition of Plasmodium falciparum Parasites from Portable Blood Levitation Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Article
- Antimicrobial mechanisms due to hyperpolarisation induced by nanoporous Au.Scientific reports · 2018Article
- Factors Diminishing Cytoadhesion of Red Blood Cells Infected by Plasmodium falciparum in Arterioles.Biophysical journal · 2017Article
- The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites.PloS one · 2017Article
- SPH-DEM approach to numerically simulate the deformation of three-dimensional RBCs in non-uniform capillaries.Biomedical engineering online · 2016Article
- Automated Fourier space region-recognition filtering for off-axis digital holographic microscopy.Biomedical optics express · 2016Article
- The development of malaria diagnostic techniques: a review of the approaches with focus on dielectrophoretic and magnetophoretic methods.Malaria journal · 2016Review
- Proteomic analysis of Plasmodium falciparum parasites from patients with cerebral and uncomplicated malaria.Scientific reports · 2016Article
- Plasmodium falciparum Secretome in Erythrocyte and Beyond.Frontiers in microbiology · 2016Review
- Immunoprofiling of the tryptophan-rich antigen family in Plasmodium vivax.Infection and immunity · 2015Article
- Interactions between Plasmodium falciparum skeleton-binding protein 1 and the membrane skeleton of malaria-infected red blood cells.Biochimica et biophysica acta · 2015Article
- Microfluidic Strategies for Understanding the Mechanics of Cells and Cell-Mimetic Systems.Annual review of chemical and biomolecular engineering · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The asexual stage of malaria parasites of the genus Plasmodium invade red blood cells of various species including humans. After parasite invasion, red blood cells progressively acquire a new set of properties and are converted into more typical, although still simpler, eukaryotic cells by the appearance of new structures in the red blood cell cytoplasm, and new proteins at the red blood cell membrane skeleton. The red blood cell undergoes striking morphological alterations and its rheological properties are considerably altered, manifesting as red blood cells with increased membrane rigidity, reduced deformability and increased adhesiveness for a number of other cells including the vascular endothelium. Elucidation of the structural changes in the red blood cell induced by parasite invasion and maturation and an understanding of the accompanying functional alterations have the ability to considerably extend our knowledge of structure-function relationships in the normal red blood cell. Furthermore, interference with these interactions may lead to previously unsuspected means of reducing parasite virulence and may lead to the development of novel antimalarial therapeutics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.