ArticleProceedings of the National Academy of Sciences of the United States of America2002
The genome sequence of the facultative intracellular pathogen Brucella melitensis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 228 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
228 citing papers in PubMed, 1 synthesis or guideline pooled it, 548 citations in OpenAlex.
- Mapping the research landscape of immune response in human brucellosis: a bibliometric analysis.Frontiers in microbiology · 2025Pooled it
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- Ability ofMicroorganisms · 2026Article
- Nuclear Localization of Effector BPE159: A Pivotal Mechanism for Intracellular Persistence ofMicroorganisms · 2026Article
- Metabolic map of Brucellosis: From acute and chronic phase adaptation to targeted nanodrug design.Materials today. Bio · 2026Review
- Isolation of Brucella suis from cattle in India: whole genome analysis unravels potential for zoonotic transmission.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Quick screening forMicrobiology resource announcements · 2025Article
- Brucellosis in the omics era: integrative perspectives on Brucella genomic architecture, host-pathogen interactions, and disease dynamics.World journal of microbiology & biotechnology · 2025Review
- Article
- Genome phylogenetic analysis of Brucella melitensis in Northwest China.BMC microbiology · 2025Article
- Brucellosis: Bacteriology, pathogenesis, epidemiology and role of the metallophores in virulence: a review.Frontiers in cellular and infection microbiology · 2025Review
- Complete genome assembly and functional characterization ofFrontiers in cellular and infection microbiology · 2025Article
- In Silico Evaluation ofMicroorganisms · 2024Article
- Investigating the mechanism of rough phenotype in a naturally attenuatedFrontiers in medicine · 2024Article
- TheAnnual review of microbiology · 2023Review
- Molecular Mechanism of Chloramphenicol and Thiamphenicol Resistance Mediated by a Novel Oxidase, CmO, inApplied and environmental microbiology · 2023Article
- Native circulatingFrontiers in microbiology · 2023Article
- A broad-host-range lytic phage vB_VhaS-R18L as a candidate against vibriosis.Frontiers in microbiology · 2023Article
- Russian collection ofFrontiers in veterinary science · 2023Article
- Trends in the Epidemiology of Brucellosis Cases in Iran during the Last Decade.Iranian journal of public health · 2022Article
168 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brucella melitensis is a facultative intracellular bacterial pathogen that causes abortion in goats and sheep and Malta fever in humans. The genome of B. melitensis strain 16M was sequenced and found to contain 3,294,935 bp distributed over two circular chromosomes of 2,117,144 bp and 1,177,787 bp encoding 3,197 ORFs. By using the bioinformatics suite ERGO, 2,487 (78%) ORFs were assigned functions. The origins of replication of the two chromosomes are similar to those of other alpha-proteobacteria. Housekeeping genes, including those involved in DNA replication, transcription, translation, core metabolism, and cell wall biosynthesis, are distributed on both chromosomes. Type I, II, and III secretion systems are absent, but genes encoding sec-dependent, sec-independent, and flagella-specific type III, type IV, and type V secretion systems as well as adhesins, invasins, and hemolysins were identified. Several features of the B. melitensis genome are similar to those of the symbiotic Sinorhizobium meliloti.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.