ArticleProceedings of the National Academy of Sciences of the United States of America2002
Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 75 citations in OpenAlex.
- Trial
- Signaling pathways regulating the extracellular digestion of lipoprotein aggregates by macrophages.Molecular biology of the cell · 2024Article
- Krüppel-like factor 2: a central regulator of B cell differentiation and plasma cell homing.Frontiers in immunology · 2023Review
- BTK inhibition limits B-cell-T-cell interaction through modulation of B-cell metabolism: implications for multiple sclerosis therapy.Acta neuropathologica · 2022Article
- Vascular Impact of Cancer Therapies: The Case of BTK (Bruton Tyrosine Kinase) Inhibitors.Circulation research · 2021Review
- IBL-202 is synergistic with venetoclax in CLL under in vitro conditions that mimic the tumor microenvironment.Blood advances · 2020Article
- Is There a Role for Dual PI3K/mTOR Inhibitors for Patients Affected with Lymphoma?International journal of molecular sciences · 2020Review
- KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer.Cell death and differentiation · 2016Article
- Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor.Scientific reports · 2014Article
- Article
- KLF4 translation level is associated with differentiation stage of different pediatric leukemias in both cell lines and primary samples.Clinical and experimental medicine · 2013Article
- Article
- Akt and mTOR in B Cell Activation and Differentiation.Frontiers in immunology · 2012Article
- Follicular B cell trafficking within the spleen actively restricts humoral immune responses.Immunity · 2010Article
- Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells.Histology and histopathology · 2009Review
- Roles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cells.Acta biochimica et biophysica Sinica · 2008Review
- Villous B cells of the small intestine are specialized for invariant NK T cell dependence.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells.Molecular and cellular biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bruton's tyrosine kinase (Btk) acts downstream of phosphoinositide 3-kinase (PI3K) in a pathway required for B cell receptor (BCR)-dependent proliferation. We used DNA microarrays to determine what fraction of genes this pathway influences and to investigate whether PI3K and Btk mediate distinct gene regulation events. As complete loss-of-function mutations in PI3K and Btk alter B cell subpopulations and may cause compensatory changes in gene expression, we used B cells with partial loss of function in either PI3K or Btk. Only about 5% of the BCR-dependent gene expression changes were significantly affected by reduced PI3K or Btk. The results indicate that PI3K and Btk share target genes, and that PI3K influences additional genes independently of Btk. These data are consistent with PI3K acting through Btk and other effectors to regulate expression of a critical subset of BCR target genes that determine effective entry into the cell cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.