ArticleProceedings of the National Academy of Sciences of the United States of America2002
Short interspersed transposable elements (SINEs) are excluded from imprinted regions in the human genome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 155 citations in OpenAlex.
- Role of long interspersed nuclear element-1 in the regulation of chromatin landscapes and genome dynamics.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- The L1-dependant and Pol III transcribed Alu retrotransposon, from its discovery to innate immunity.Molecular biology reports · 2021Review
- A Mechanism Leading to Changes in Copy Number Variations Affected by Transcriptional Level Might Be Involved in Evolution, Embryonic Development, Senescence, and Oncogenesis Mediated by Retrotransposons.Frontiers in cell and developmental biology · 2021Article
- Conservation of Repeats at the Mammalian KCNQ1OT1-CDKN1C Region Suggests a Role in Genomic Imprinting.Evolutionary bioinformatics online · 2017Article
- Bipartite structure of the inactive mouse X chromosome.Genome biology · 2015Article
- Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites.Genome research · 2015Article
- DNA methylation profiling in X;autosome translocations supports a role for L1 repeats in the spread of X chromosome inactivation.Human molecular genetics · 2014Article
- Genome-wide histone state profiling of fibroblasts from the opossum, Monodelphis domestica, identifies the first marsupial-specific imprinted gene.BMC genomics · 2014Article
- Type I error control for tree classification.Cancer informatics · 2014Article
- Imprinting of cerebral and hepatic cytochrome p450s in rat offsprings exposed prenatally to low doses of cypermethrin.Molecular neurobiology · 2013Article
- Subpopulation-specific confidence designation for more informative biomedical classification.Artificial intelligence in medicine · 2013Article
- Article
- SINE retrotransposons cause epigenetic reprogramming of adjacent gene promoters.Molecular cancer research : MCR · 2012Article
- Genomic imprinting: recognition and marking of imprinted loci.Current opinion in genetics & development · 2012Review
- L1 hybridization enrichment: a method for directly accessing de novo L1 insertions in the human germline.Human mutation · 2011Article
- Unique patterns of evolutionary conservation of imprinted genes.Clinical epigenetics · 2011Article
- Distributions of transposable elements reveal hazardous zones in mammalian introns.PLoS computational biology · 2011Article
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- Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes.Development (Cambridge, England) · 2011Article
- A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes.Genome research · 2011Article
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1 author at 1 institution in 1 country.
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Abstract
To test whether regions undergoing genomic imprinting have unique genomic characteristics, imprinted and nonimprinted human loci were compared for nucleotide and retroelement composition. Maternally and paternally expressed subgroups of imprinted genes were found to differ in terms of guanine and cytosine, CpG, and retroelement content, indicating a segregation into distinct genomic compartments. Imprinted regions have been normally permissive to L1 long interspersed transposable element retroposition during mammalian evolution but universally and significantly lack short interspersed transposable elements (SINEs). The primate-specific Alu SINEs, as well as the more ancient mammalian-wide interspersed repeat SINEs, are found at significantly low densities in imprinted regions. The latter paleogenomic signature indicates that the sequence characteristics of currently imprinted regions existed before the mammalian radiation. Transitions from imprinted to nonimprinted genomic regions in cis are characterized by a sharp inflection in SINE content, demonstrating that this genomic characteristic can help predict the presence and extent of regions undergoing imprinting. During primate evolution, SINE accumulation in imprinted regions occurred at a decreased rate compared with control loci. The constraint on SINE accumulation in imprinted regions may be mediated by an active selection process. This selection could be because of SINEs attracting and spreading methylation, as has been found at other loci. Methylation-induced silencing could lead to deleterious consequences at imprinted loci, where inactivation of one allele is already established, and expression is often essential for embryonic growth and survival.
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