ArticleMolecular and cellular biology2002
Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- Mutations in the acetylation hotspots of Rbl2 are associated with increased risk of breast cancer.PloS one · 2022Article
- Ki-67 gene expression.Cell death and differentiation · 2021Article
- Biallelic loss-of-function variants in RBL2 in siblings with a neurodevelopmental disorder.Annals of clinical and translational neurology · 2020Article
- RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines.Oncogene · 2018Article
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- The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency.The Journal of biological chemistry · 2015Article
- The association of mammalian DREAM complex and HPV16 E7 proteins.American journal of cancer research · 2015Review
- The DREAM complex in antitumor activity of imatinib mesylate in gastrointestinal stromal tumors.Current opinion in oncology · 2014Review
- LIN54 harboring a mutation in CHC domain is localized to the cytoplasm and inhibits cell cycle progression.Cell cycle (Georgetown, Tex.) · 2012Article
- Overexpression of cyclin E/CDK2 complexes overcomes FGF-induced cell cycle arrest in the presence of hypophosphorylated Rb proteins.Cell cycle (Georgetown, Tex.) · 2012Article
- The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle.Cell division · 2012Article
- Induction of Wnt/β-catenin signaling in mouse mesenchymal stem cells is associated with activation of the p130 and E2f4 and formation of the p130/Gsk3β/β-catenin complex.Stem cells and development · 2012Article
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- E2F-1 has dual roles depending on the cell cycle.International journal of biological sciences · 2010Article
- pRb2/p130 protein expression and RBL2 mutation analysis in Burkitt lymphoma from Uganda.BMC clinical pathology · 2009Article
- Expression and localization of Ski determine cell type-specific TGFbeta signaling effects on the cell cycle.The Journal of cell biology · 2008Article
- Article
- E2F4 function in G2: maintaining G2-arrest to prevent mitotic entry with damaged DNA.Cell cycle (Georgetown, Tex.) · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The retinoblastoma-related pocket proteins pRb, p107, and p130 are implicated in the control of cell proliferation, differentiation, and transformation. The function of pocket proteins is in part mediated by their ability to inhibit specific E2F transcription factors. The transcriptional activity of E2Fs is controlled by alteration of their nucleocytoplasmic localization during the cell cycle. p130 was observed to shuttle between the nucleus and cytoplasm in a heterokaryon fusion assay, suggesting the presence of nuclear and cytoplasmic localization signals. Two independent nuclear localization signals (NLS) that could target reporter proteins to the nucleus in transient transfection and microinjection experiments were identified in the C terminus of p130. In addition to the C-terminal NLS, the intact pocket domain of p130 itself was sufficient for nuclear translocation. Moreover, an additional functional NLS was mapped within the unique Loop region of p130. An N-terminal domain that conferred cytoplasmic localization was identified. Removal of the entire N terminus did not affect the ability of p130 to interact with E2F and to induce growth arrest. A model suggesting that the activity of pRb family members can be regulated by intracellular trafficking of the proteins is proposed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.