ArticleMolecular and cellular biology2002
Role for Hes1-induced phosphorylation in Groucho-mediated transcriptional repression.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
- Systemic degradation of repressive transcription factors gates gene expression and cell fate specification.bioRxiv : the preprint server for biology · 2026Article
- Downy Mildew effector HaRxL21 interacts with the transcriptional repressor TOPLESS to promote pathogen susceptibility.PLoS pathogens · 2020Article
- Chimeric NANOG repressors inhibit glioblastoma growth in vivo in a context-dependent manner.Scientific reports · 2019Article
- Groucho related gene 5 (GRG5) is involved in embryonic and neural stem cell state decisions.Scientific reports · 2018Article
- Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation.ACS omega · 2018Article
- Wogonin induces retinal neuron-like differentiation of bone marrow stem cells by inhibiting Notch-1 signaling.Oncotarget · 2017Article
- Protein kinase CK2 in development and differentiation.Biomedical reports · 2017Article
- Unraveling the differential dynamics of developmental fate in central and peripheral nervous systems.Scientific reports · 2016Article
- Hes1: the maestro in neurogenesis.Cellular and molecular life sciences : CMLS · 2016Review
- The Groucho/Transducin-like enhancer of split protein family in animal development.IUBMB life · 2015Review
- Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiation.Cell death and differentiation · 2014Article
- EAR motif-mediated transcriptional repression in plants: an underlying mechanism for epigenetic regulation of gene expression.Epigenetics · 2011Article
- Transcriptional repression: conserved and evolved features.Current biology : CB · 2010Review
- FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation.Development (Cambridge, England) · 2010Article
- Cofactor-activated phosphorylation is required for inhibition of cortical neuron differentiation by Groucho/TLE1.PloS one · 2009Article
- Hes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genes.PloS one · 2009Article
- Modeling the dynamics of transcriptional gene regulatory networks for animal development.Developmental biology · 2009Review
- The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors.The Biochemical journal · 2009Article
- Expression of Groucho/TLE proteins during pancreas development.BMC developmental biology · 2008Article
- Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcriptional corepressors of the Groucho/transducin-like Enhancer of split (Gro/TLE) family regulate a number of developmental pathways in both invertebrates and vertebrates. They form transcription repression complexes with members of several DNA-binding protein families and participate in the regulation of the expression of numerous genes. Despite their pleiotropic roles, little is known about the mechanisms that regulate the functions of Gro/TLE proteins. It is shown here that Gro/TLEs become hyperphosphorylated in response to neural cell differentiation and interaction with the DNA-binding cofactor Hairy/Enhancer of split 1 (Hes1). Hyperphosphorylation of Gro/TLEs is correlated with a tight association with the nuclear compartment through interaction with chromatin, suggesting that hyperphosphorylated Gro/TLEs may mediate transcriptional repression via chromatin remodeling mechanisms. Pharmacological inhibition of protein kinase CK2 reduces the Hes1-induced hyperphosphorylation of Gro/TLEs and causes a decrease in the chromatin association of the latter. Moreover, the transcription repression activity of Gro/TLEs is reduced by protein kinase CK2 inhibition. Consistent with these observations, Gro/TLEs are phosphorylated in vitro by purified protein kinase CK2. Taken together, these results implicate protein kinase CK2 in Gro/TLE functions. They suggest further that this kinase is involved in a hyperphosphorylation mechanism activated by Hes1 that promotes the transcription repression functions of Hes1-Gro/TLE protein complexes.
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