ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
The tripotential glial-restricted precursor (GRP) cell and glial development in the spinal cord: generation of bipotential oligodendrocyte-type-2 astrocyte progenitor cells and dorsal-ventral differences in GRP cell function.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed.
- Single cell RNAseq to identify subpopulations of glial progenitors in iPSC-derived oligodendroglial lineage cultures.NPJ systems biology and applications · 2025Article
- The epigenetic landscape of oligodendrocyte lineage cells.Annals of the New York Academy of Sciences · 2023Review
- Review
- Chemobrain as a Product of Growing Success in Chemotherapy - Focus on Glia as both a Victim and a Cure.Neuropsychiatry · 2019Article
- Human Spinal Oligodendrogenic Neural Progenitor Cells Promote Functional Recovery After Spinal Cord Injury by Axonal Remyelination and Tissue Sparing.Stem cells translational medicine · 2018Article
- EGF Enhances Oligodendrogenesis from Glial Progenitor Cells.Frontiers in molecular neuroscience · 2017Article
- Glial-Restricted Precursors Protect Neonatal Brain Slices from Hypoxic-Ischemic Cell Death Without Direct Tissue Contact.Stem cells and development · 2016Article
- A Novel Approach for Amplification and Purification of Mouse Oligodendrocyte Progenitor Cells.Frontiers in cellular neuroscience · 2016Article
- Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases.Trends in molecular medicine · 2015Review
- Serine/threonine-protein kinase PFTK1 modulates oligodendrocyte differentiation via PI3K/AKT pathway.Journal of molecular neuroscience : MN · 2015Article
- Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury.World journal of stem cells · 2015Review
- Transplantation of glial progenitors that overexpress glutamate transporter GLT1 preserves diaphragm function following cervical SCI.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- Characterization of glial-restricted precursors from rhesus monkey embryonic stem cells.Translational neuroscience · 2015Article
- Synergistic actions of olomoucine and bone morphogenetic protein-4 in axonal repair after acute spinal cord contusion.Neural regeneration research · 2014Article
- Astroglial-derived periostin promotes axonal regeneration after spinal cord injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Effect of type-2 astrocytes on the viability of dorsal root ganglion neurons and length of neuronal processes.Neural regeneration research · 2014Article
- ASYMMETRIC CELL DIVISION: IMPLICATIONS FOR GLIOMA DEVELOPMENT AND TREATMENT.Translational neuroscience · 2013Article
- Oligodendrocyte/type-2 astrocyte progenitor cells and glial-restricted precursor cells generate different tumor phenotypes in response to the identical oncogenes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Human embryonic stem cell-derived oligodendrocytes: protocols and perspectives.Stem cells and development · 2013Review
- Combined transplantation of GDAs(BMP) and hr-decorin in spinal cord contusion repair.Neural regeneration research · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We have found that the tripotential glial-restricted precursor (GRP) cell of the embryonic rat spinal cord can give rise in vitro to bipotential cells that express defining characteristics of oligodendrocyte-type-2 astrocyte progenitor cells (O2A/OPCs). Generation of O2A/OPCs is regulated by environmental signals and is promoted by platelet-derived growth factor (PDGF), thyroid hormone (TH) and astrocyte-conditioned medium. In contrast to multiple observations indicating that oligodendrocyte precursor cells in the embryonic day 14 (E14) spinal cord are ventrally restricted, GRP cells are already present in both the dorsal and ventral spinal cord at E13.5. Ventral-derived GRP cells, however, were more likely to generate O2A/OPCs and/or oligodendrocytes than were their dorsal counterparts when exposed to TH, PDGF, or even bone morphogenetic protein-4. The simplest explanation of our results is that oligodendrocyte generation occurs as a result of generation of GRP cells from totipotent neuroepithelial stem cells, of O2A/OPCs from GRP cells and, finally, of oligodendrocytes from O2A/OPCs. In this respect, the responsiveness of GRP cells to modulators of this process may represent a central control point in the initiation of this critical developmental sequence. Our findings provide an integration between the earliest known glial precursors and the well-studied O2A/OPCs while opening up new questions concerning the intricate spatial and temporal regulation of precursor cell differentiation in the CNS.
Indexed as
Identifiers
11756508PMC6757619What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.