ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Jerky, a protein deficient in a mouse epilepsy model, is associated with translationally inactive mRNA in neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
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- The Role of Transposable Elements of the Human Genome in Neuronal Function and Pathology.International journal of molecular sciences · 2022Review
- Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective.Journal of developmental biology · 2018Review
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- Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.PLoS genetics · 2017Article
- Putative CENP-B paralogues are not present at mammalian centromeres.Chromosoma · 2012Article
- Genetic innovation in vertebrates: gypsy integrase genes and other genes derived from transposable elements.International journal of evolutionary biology · 2012Article
- CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function.PLoS genetics · 2012Article
- Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity.The EMBO journal · 2011Article
- Confirmation of multiple seizure susceptibility QTLs on chromosome 15 in C57BL/6J and DBA/2J inbred mice.Physiological genomics · 2010Article
- Drosophila couch potato mutants exhibit complex neurological abnormalities including epilepsy phenotypes.Genetics · 2005Article
- Protein coding potential of retroviruses and other transposable elements in vertebrate genomes.Nucleic acids research · 2005Article
- Variability in the benzodiazepine response of serotonin 5-HT1A receptor null mice displaying anxiety-like phenotype: evidence for genetic modifiers in the 5-HT-mediated regulation of GABA(A) receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- The RNA binding domain of Jerky consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Temporal lobe epilepsy (TLE) is a common seizure disorder, but the underlying molecular mechanisms are unknown. We reported previously that inactivation of the jerky gene in mice causes recurrent limbic seizures highly similar to TLE. Electrophysiological studies showed abnormal firing in hippocampal neurons in these mice, but it is not known how a deficiency in the Jerky protein leads to neuronal hyperexcitability. Here we show that Jerky is a brain-specific protein with a high expression level in neurons. Jerky binds mRNAs with high affinity, and it is a component of messenger ribonucleoprotein complexes in vivo. However, Jerky is not associated with ribosomes and actively translating mRNAs. These data suggest that Jerky may regulate mRNA use in neurons, and its deficiency could lead to perturbations in the regulated use of preexisting mRNAs.
Indexed as
Identifiers
11756500PMC6757593W2160654702What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.