ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Synaptic potentials mediated by alpha 7 nicotinic acetylcholine receptors in supraoptic nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- Differential Regulation of Prelimbic and Thalamic Transmission to the Basolateral Amygdala by Acetylcholine Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators.Molecules (Basel, Switzerland) · 2023Review
- Nicotinic ACh receptors as therapeutic targets in CNS disorders.Trends in pharmacological sciences · 2015Review
- Characteristics of GABAergic and cholinergic neurons in perinuclear zone of mouse supraoptic nucleus.Journal of neurophysiology · 2015Article
- Physiological regulation of magnocellular neurosecretory cell activity: integration of intrinsic, local and afferent mechanisms.Journal of neuroendocrinology · 2013Review
- Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum.Advances in experimental medicine and biology · 2012Review
- Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences.Journal of neurophysiology · 2011Article
- Fast synaptic transmission in the goldfish CNS mediated by multiple nicotinic receptors.The Journal of physiology · 2011Article
- Beyond the cholinergic hypothesis: do current drugs work in Alzheimer's disease?CNS neuroscience & therapeutics · 2010Review
- Alpha 7 nicotinic acetylcholine receptor expression and activity during neuronal differentiation of PC12 pheochromocytoma cells.Journal of molecular neuroscience : MN · 2010Article
- The adaptive brain: Glenn Hatton and the supraoptic nucleus.Journal of neuroendocrinology · 2010Review
- Synchronous and asynchronous transmitter release at nicotinic synapses are differentially regulated by postsynaptic PSD-95 proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Article
- Four excitatory postsynaptic ionotropic receptors coactivated at the motoneuron-Renshaw cell synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Endogenous modulators of synaptic transmission: cannabinoid regulation in the supraoptic nucleus.Progress in brain research · 2008Review
- Role of endogenous nicotinic signaling in guiding neuronal development.Biochemical pharmacology · 2007Review
- Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors.Biochemical pharmacology · 2007Review
- Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons.The Journal of physiology · 2007Article
- Functional somato-dendritic alpha7-containing nicotinic acetylcholine receptors in the rat basolateral amygdala complex.The Journal of physiology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Brain slice preparations preserving projections from nearby forebrain cholinergic neurons to the supraoptic nucleus (SON) were used to study synaptic potentials mediated by nicotinic acetylcholine receptors (nAChRs) in the hypothalamus. Paired-pulse electrical stimulation in an area anterior to the SON that was rich in cholinergic cells confirmed the monosynaptic nature of the connections to putative oxytocin and vasopressin SON neurons. With ionotropic glutamate and GABA(A) transmission blocked, this stimulation evoked fast, atropine-insensitive EPSPs that were sensitive to nAChR antagonists. Evoked EPSPs were blocked by methyllycaconitine and alpha-bungarotoxin, antagonists that are selective for nAChRs containing the alpha7 subunit, but not by dihydro-beta-erythroidine at concentrations known to antagonize alpha4beta2 nAChRs. Although anatomical evidence exists for postsynaptic alpha4beta2 nAChRs in the SON, these results indicate that postsynaptic alpha7 nAChRs are primarily responsible for the cholinergically mediated EPSPs. Repetitive stimulation suggested partial desensitization of the receptors. With ionotropic glutamate transmission blocked, inhibition of AChE increased spontaneous EPSP frequency and amplitude, suggesting spontaneous ACh release. ACh, nicotine, and choline (a selective alpha7 nAChR agonist) were effective in evoking action potentials and repetitive firing with synaptic transmission blocked by low Ca2+, high Mg2+ medium. These agonists were also effective in evoking the type of phasic bursts characteristic of vasopressin neurons, long thought to be completely dependent on activation of NMDA receptors (NMDARs). Because phasic bursting is Ca2+-dependent, the functional equivalence of alpha7 nAChR and NMDAR activation in this regard is likely attributable to their large Ca2+ fluxing capacities. This is the first demonstration that synaptically released ACh results in fast, alpha7 nAChR-mediated EPSPs in hypothalamic neurons.
Indexed as
Identifiers
11756485PMC6757599W2154405330What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.