ArticleOncogene2001
Overexpression of bone morphogenetic protein-6 (BMP-6) in murine epidermis suppresses skin tumor formation by induction of apoptosis and downregulation of fos/jun family members.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Antifibrogenic Activities of CYP11A1-derived Vitamin D3-hydroxyderivatives Are Dependent on RORγ.Endocrinology · 2021Article
- Characterization of Embryonic Skin Transcriptome inG3 (Bethesda, Md.) · 2020Article
- Silibinin inhibits ultraviolet B radiation-induced mast cells recruitment and bone morphogenetic protein 2 expression in the skin at early stages in Ptch(+/-) mouse model of basal cell carcinoma.Molecular carcinogenesis · 2019Article
- Expression of bone morphogenetic protein 6 in non-small cell lung cancer and its significance.Oncology letters · 2019Article
- Human Induced Pluripotent Stem Cells Differentiate Into Functional Mesenchymal Stem Cells and Repair Bone Defects.Stem cells translational medicine · 2016Article
- Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration.The Journal of investigative dermatology · 2014Article
- Hypermethylation leads to bone morphogenetic protein 6 downregulation in hepatocellular carcinoma.PloS one · 2014Article
- Gene expression profiling associated with angiotensin II type 2 receptor-induced apoptosis in human prostate cancer cells.PloS one · 2014Article
- Association of bone morphogenetic protein 6 with exocrine gland dysfunction in patients with Sjögren's syndrome and in mice.Arthritis and rheumatism · 2013Article
- Myo/Nog cells in normal, wounded and tumor-bearing skin.Experimental dermatology · 2012Article
- Imaging bone morphogenetic protein 7 induced cell cycle arrest in experimental gliomas.Neoplasia (New York, N.Y.) · 2011Article
- Constitutive activation of BMP signalling abrogates experimental metastasis of OVCA429 cells via reduced cell adhesion.Journal of ovarian research · 2010Article
- Multiple signaling pathways converge to regulate bone-morphogenetic-protein-dependent glial gene expression.Developmental neuroscience · 2009Article
- Execution of BMP-4-induced apoptosis by p53-dependent ER dysfunction in myeloma and B-cell hybridoma cells.Oncogene · 2006Article
- Interaction between the bone morphogenetic proteins and Ras/MAP-kinase signalling pathways in lung cancer.British journal of cancer · 2005Article
- BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1.BMC immunology · 2005Article
- Bone morphogenetic protein-5, -6 and -7 inhibit growth and induce apoptosis in human myeloma cells.Oncogene · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone morphogenetic protein-6 (BMP-6) is a member of the transforming growth factor-beta superfamily. In murine skin, BMP-6 is highly expressed in postmitotic keratinocytes from day 15.5 p.c. till day 6 p.p. Expression in adult skin remains at very low levels, but pathological conditions such as wounding induce the expression of BMP-6. We demonstrate that tumor promotion by TPA (12-O-tetradecanoylphorbol-13-acetate) also induces expression of BMP-6 in suprabasal keratinocytes. This induction is due to post-transcriptional regulation since the level of BMP-6 mRNA remained unchanged. We performed two-stage skin carcinogenesis experiments with transgenic mice epidermally overexpressing BMP-6. These mice display augmented mitotic indices in normal and TPA-treated epidermis when compared to controls. Despite this hyperproliferation, BMP-6 transgenics showed a delayed development and strong suppression of benign and malignant skin tumor formation. In order to resolve this paradox we determined apoptotic frequencies as well as the expression of constituents of AP-1 (activator protein-1) which is essential for tumor promotion. A higher rate of apoptotic keratinocytes was detectable in transgenic mice versus controls and a downregulation of mRNA for jun/fos family members in transgenic skin after TPA-treatment. Thus expression of BMP-6 augments apoptosis and downregulates the transcription of AP-1 family members thereby establishing tumor resistance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.