ArticleProceedings of the National Academy of Sciences of the United States of America2001
Siah-1 binds and regulates the function of Numb.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
- The CRL7Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Zika Virus Induces Degradation of the Numb Protein Required through Embryonic Neurogenesis.Viruses · 2023Article
- Interactome Mapping Uncovers a General Role for Numb in Protein Kinase Regulation.Molecular & cellular proteomics : MCP · 2018Article
- Review
- Seven in Absentia E3 Ubiquitin Ligases: Central Regulators of Neural Cell Fate and Neuronal Polarity.Frontiers in cellular neuroscience · 2017Review
- Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy.Oncotarget · 2016Article
- Network Modeling Identifies Patient-specific Pathways in Glioblastoma.Scientific reports · 2016Article
- ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2.The Biochemical journal · 2016Article
- Inducing stable reversion to achieve cancer control.Nature reviews. Cancer · 2016Review
- UV-Induced Wnt7a in the Human Skin Microenvironment Specifies the Fate of Neural Crest-Like Cells via Suppression of Notch.The Journal of investigative dermatology · 2015Article
- Infant sex-specific placental cadmium and DNA methylation associations.Environmental research · 2015Article
- SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status.Cell cycle (Georgetown, Tex.) · 2015Article
- Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer.Nature reviews. Urology · 2014Review
- Aberrant regulation of FBW7 in cancer.Oncotarget · 2014Review
- The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1.Nature medicine · 2014Article
- Numb and Alzheimer's disease: the current picture.Frontiers in neuroscience · 2012Article
- Reciprocal repression between P53 and TCTP.Nature medicine · 2011Article
- Eukaryotic translation elongation factor 1 delta inhibits the ubiquitin ligase activity of SIAH-1.Molecular and cellular biochemistry · 2011Article
- Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila Seven in absentia (Sina) gene product originally was described as a protein that controls cell fate decisions during eye development. Its mammalian homolog, Siah-1, recently was found to be involved in p53-dependent and -independent pathways of apoptosis and G(1) arrest. We report that Siah-1 interacts directly with and promotes the degradation of the cell fate regulator Numb. Siah-1-mediated Numb degradation leads to redistribution of endogenous cell-surface Notch to the cytoplasm and nucleus and to augmented Notch-regulated transcriptional activity. These data imply that through its ability to target Numb for degradation, Siah-1 can act as a key regulator of Numb-related activities, including Notch signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.