ArticleProceedings of the National Academy of Sciences of the United States of America2001
A receptor tyrosine kinase from choanoflagellates: molecular insights into early animal evolution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 229 citations in OpenAlex.
- What comparative endocrinology tells us about the original function of the insulin superfamily.Endocrine journal · 2025Review
- Phylogenetic and transcriptomic characterization of insulin and growth factor receptor tyrosine kinases in crustaceans.Frontiers in endocrinology · 2024Article
- Review
- What is it like to be a choanoflagellate? Sensation, processing and behavior in the closest unicellular relatives of animals.Animal cognition · 2023Review
- Cross-kingdom analyses of transmembrane protein kinases show their functional diversity and distinct origins in protists.Computational and structural biotechnology journal · 2023Article
- Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis.PloS one · 2023Article
- The draft genome of Cochliopodium minus reveals a complete meiosis toolkit and provides insight into the evolution of sexual mechanisms in Amoebozoa.Scientific reports · 2022Article
- Domain Analysis and Motif Matcher (DAMM): A Program to Predict Selectivity Determinants inMolecules (Basel, Switzerland) · 2021Article
- Embryo, larval, and juvenile staging of Lytechinus pictus from fertilization through sexual maturation.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Conceptual Evolution of Cell Signaling.International journal of molecular sciences · 2019Review
- The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases.Critical reviews in biochemistry and molecular biology · 2018Review
- The Origin of Animal Multicellularity and Cell Differentiation.Developmental cell · 2017Review
- On the origin of biological construction, with a focus on multicellularity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Phosphotyrosine signalling and the origin of animal multicellularity.Proceedings. Biological sciences · 2017Article
- Spheres of Hope, Packets of Doom: the Good and Bad of Outer Membrane Vesicles in Interspecies and Ecological Dynamics.Journal of bacteriology · 2017Review
- Phylogenetic evidence for the modular evolution of metazoan signalling pathways.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.PLoS genetics · 2016Article
- The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling.Genome biology and evolution · 2015Article
- Article
- Control of Ras-mediated signaling in Aspergillus fumigatus.Mycopathologia · 2014Review
3 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The evolution of the Metazoa from protozoans is one of the major milestones in life's history. The genetic and developmental events involved in this evolutionary transition are unknown but may have involved the evolution of genes required for signaling and gene regulation in metazoans. The genome of animal ancestors may be reconstructed by identification of animal genes that are shared with related eukaryotes, particularly those that share a more recent ancestry and cell biology with animals. The choanoflagellates have long been suspected to be closer relatives of animals than are fungi, the closest outgroup of animals for which comparative genomic information is available. Phylogenetic analyses of choanoflagellate and animal relationships based on small subunit rDNA sequence, however, have yielded ambiguous and conflicting results. We find that analyses of four conserved proteins from a unicellular choanoflagellate, Monosiga brevicollis, provide robust support for a close relationship between choanoflagellates and Metazoa, suggesting that comparison of the complement of expressed genes from choanoflagellates and animals may be informative concerning the early evolution of metazoan genomes. We have discovered in M. brevicollis the first receptor tyrosine kinase (RTK), to our knowledge, identified outside of the Metazoa, MBRTK1. The architecture of MBRTK1, which includes multiple extracellular ligand-binding domains, resembles that of RTKs in sponges and humans and suggests the ability to receive and transduce signals. Thus, choanoflagellates express genes involved in animal development that are not found in other eukaryotes and that may be linked to the origin of the Metazoa.
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