ArticleThe Plant cell2001
Expression and stability of Arabidopsis CDC6 are associated with endoreplication.
Article in The Plant cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 151 citations in OpenAlex.
- Molecular regulation of plant endoreduplication: core mechanisms and their upstream control.Plant molecular biology · 2026Review
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- OsNLP3 enhances grain weight and reduces grain chalkiness in rice.Plant communications · 2024Article
- Endoreplication-Why Are We Not Using Its Full Application Potential?International journal of molecular sciences · 2023Review
- Distinct roles of Arabidopsis ORC1 proteins in DNA replication and heterochromatic H3K27me1 deposition.Nature communications · 2023Article
- Comparative transcriptomics reveals commonalities and differences in the genetic underpinnings of a floral dimorphism.Scientific reports · 2022Article
- A Journey to the Core of the Plant Cell Cycle.International journal of molecular sciences · 2022Review
- Transcriptome Analysis of Near-Isogenic Lines Provides Novel Insights into Genes Associated with Seed Low-Temperature Germination Ability in Maize (Plants (Basel, Switzerland) · 2022Article
- Cycling in a crowd: Coordination of plant cell division, growth, and cell fate.The Plant cell · 2022Review
- Cryptochromes and the Circadian Clock: The Story of a Very Complex Relationship in a Spinning World.Genes · 2021Review
- Control of pre-replicative complex during the division cycle in Chlamydomonas reinhardtii.PLoS genetics · 2021Article
- The Armadillo BTB Protein ABAP1 Is a Crucial Player in DNA Replication and Transcription of Nematode-Induced Galls.Frontiers in plant science · 2021Article
- Roles of plant retinoblastoma protein: cell cycle and beyond.The EMBO journal · 2020Review
- The effector GpRbp-1 of Globodera pallida targets a nuclear HECT E3 ubiquitin ligase to modulate gene expression in the host.Molecular plant pathology · 2020Article
- Asexual Female Gametogenesis Involves Contact with a Sexually-Fated Megaspore in ApomicticPlant physiology · 2018Article
- Genomic Analysis of the DNA Replication Timing Program during Mitotic S Phase in Maize (The Plant cell · 2017Article
- The plant cell cycle: Pre-Replication complex formation and controls.Genetics and molecular biology · 2017Article
- A Co-Opted Hormonal Cascade Activates Dormant Adventitious Root Primordia upon Flooding in Solanum dulcamara.Plant physiology · 2016Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies on the CDC6 protein, which is crucial to the control of DNA replication in yeast and animal cells, are lacking in plants. We have isolated an Arabidopsis cDNA encoding the AtCDC6 protein and studied its possible connection to the occurrence of developmentally regulated endoreplication cycles. The AtCDC6 gene is expressed maximally in early S-phase, and its promoter contains an E2F consensus site that mediates the binding of a plant E2F/DP complex. Transgenic plants carrying an AtCDC6 promoter-beta-glucuronidase fusion revealed that it is active in proliferating cells and, interestingly, in endoreplicating cells. In particular, the extra endoreplication cycle that occurs in dark-grown hypocotyl cells is associated with upregulation of the AtCDC6 gene. This was corroborated using ctr1 Arabidopsis mutants altered in their endoreplication pattern. The ectopic expression of AtCDC6 in transgenic plants induced endoreplication and produced a change in the somatic ploidy level. AtCDC6 was degraded in a ubiquitin- and proteosome-dependent manner by extracts from proliferating cells, but it was degraded poorly by extracts from dark-grown hypocotyl endoreplicating cells. Our results indicate that endoreplication is associated with expression of the AtCDC6 gene and, most likely, the stability of its product; it also apparently requires activation of the retinoblastoma/E2F/DP pathway. These conclusions may apply to endoreplicating cells in other tissues of the plant and to endoreplicating cells in other eukaryotes.
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