ArticleThe Journal of biological chemistry2002
Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice.
Article in The Journal of biological chemistry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Trial
- EBF2 variant identified in a patient with atypical partial lipodystrophy causes adipose fibrosis and dysfunction.The Journal of clinical investigation · 2026Article
- Dietary Bamboo Charcoal Decreased Visceral Adipose Tissue Weight by Enhancing Fecal Lipid Excretions in Mice with High-Fat Diet-Induced Obesity.Preventive nutrition and food science · 2023Article
- Structure and Function of Pancreatic Lipase-Related Protein 2 and Its Relationship With Pathological States.Frontiers in genetics · 2021Review
- Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function.PLoS genetics · 2020Article
- Effects of thylakoid intake on appetite and weight loss: a systematic review.Journal of diabetes and metabolic disorders · 2020Review
- Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans.Molecular nutrition & food research · 2017Review
- Thylakoids reduce body fat and fat cell size by binding to dietary fat making it less available for absorption in high-fat fed mice.Nutrition & metabolism · 2017Article
- Time-course microarray analysis for identifying candidate genes involved in obesity-associated pathological changes in the mouse colon.Genes & nutrition · 2016Article
- The Use of Green Leaf Membranes to Promote Appetite Control, Suppress Hedonic Hunger and Loose Body Weight.Plant foods for human nutrition (Dordrecht, Netherlands) · 2015Article
- A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding.Biochimica et biophysica acta · 2015Article
- Role of the gut in modulating lipoprotein metabolism.Current cardiology reports · 2014Review
- The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding.Journal of lipid research · 2013Article
- Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance, and hepatosteatosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns.The Journal of biological chemistry · 2011Article
- Kinetic properties of mouse pancreatic lipase-related protein-2 suggest the mouse may not model human fat digestion.Journal of lipid research · 2011Article
- Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice.American journal of physiology. Endocrinology and metabolism · 2009Article
- Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity.Journal of leukocyte biology · 2009Article
- Intestinal lipid absorption.American journal of physiology. Endocrinology and metabolism · 2009Review
- Procolipase gene: no association with early-onset obesity or fat intake.Obesity facts · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
In vitro, pancreatic triglyceride lipase requires colipase to restore activity in the presence of inhibitors, like bile acids. Presumably, colipase performs the same function in vivo, but little data supports that notion. Other studies suggest that colipase or its proform, procolipase, may have additional functions in appetite regulation or in fat digestion during the newborn period when pancreatic triglyceride lipase is not expressed. To identify the physiological role of procolipase, we created a mouse model of procolipase deficiency. The Clps-/- mice appeared normal at birth, but unexpectedly 60% died within the first 2 weeks of life. The survivors had fat malabsorption as newborns and as adults, but only when fed a high fat diet. On a low fat diet, the Clps-/- mice did not have steatorrhea. The Clps-/- pups had impaired weight gain and weighed 30% less than Clps+/+ or Clps+/- littermates. After weaning, the Clps-/- mice had normal rate of weight gain, but they maintained a reduced body weight compared with normal littermates even on a low fat diet. Despite the reduced body weight, the Clps-/- mice had a normal body temperature. To maintain their weight gain in the presence of steatorrhea, the Clps-/- mice had hyperphagia on a high fat diet. Clps-/- mice had normal intake on a low fat diet. We conclude that, in addition to its critical role in fat digestion, procolipase has essential functions in postnatal development and in regulating body weight set point.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.